Pirch J H, Napier T C, Corbus M J
Int J Neurosci. 1981;15(4):217-22. doi: 10.3109/00207458108985859.
Slow potential (SP) responses were recorded bilaterally from the frontal cortex of rats with permanently implanted silver-silver chloride electrodes. Trials were presented at variable intervals from 15 to 50 sec and the interval between the pulse cue and onset of the rewarding train was 2 sec. The cue stimulus was a single 0.5 msec monophasic square wave pulse of the same current intensity as rewarding stimulation (100 Hz, 500 msec train). Appropriate current strength was determined by prior testing for self-stimulation. The single pulse by itself failed to evoke an SP response but after repeated pairings, large negative SP responses developed which were bilaterally equal. These responses extinguished rapidly when rewarding stimulation was discontinued. d-Amphetamine (0.125, 0.25 and 0.5 mg/kg, SC) produced a dose-related depression of the SP response to the pulse cue, an effect comparable to that observed using an auditory cue with either food or MFB stimulation reinforcement. The results indicate that frontal cortex SP responses which develop in anticipation of a meaningful event do not require a peripheral sensory cue. Furthermore, amphetamine suppression of these SP responses is not produced via a disruption of the auditory system.
使用永久植入的银-氯化银电极，从大鼠双侧额叶皮质记录慢电位（SP）反应。试验以15至50秒的可变间隔进行呈现，脉冲提示与奖励性刺激串开始之间的间隔为2秒。提示刺激是一个0.5毫秒的单相方波脉冲，其电流强度与奖励性刺激相同（100赫兹，500毫秒刺激串）。通过先前的自我刺激测试确定适当的电流强度。单个脉冲本身未能引发SP反应，但经过重复配对后，出现了双侧相等的大的负向SP反应。当奖励性刺激停止时，这些反应迅速消失。右旋苯丙胺（0.125、0.25和0.5毫克/千克，皮下注射）对脉冲提示的SP反应产生剂量相关的抑制作用，这种作用与使用食物或内侧前脑束刺激强化的听觉提示所观察到的作用相当。结果表明，在预期有意义事件时出现的额叶皮质SP反应不需要外周感觉提示。此外，苯丙胺对这些SP反应的抑制作用不是通过破坏听觉系统产生的。
