Studies on beta-lactam antibiotics. II. Synthesis and structure-activity relationships of alpha-hydroxyiminoarylacetyl cephalosporins.
作者信息
Takaya T, Takasugi H, Masugi T, Kochi H, Nakano H
出版信息
J Antibiot (Tokyo). 1981 Oct;34(10):1290-9. doi: 10.7164/antibiotics.34.1290.
PMID:7309623
Abstract
The synthesis and antibacterial activity in vitro of the 2-aryl-2-hydroxyiminoacetyl cephalosporins (2) are described. Within this cephalosporin series, analogs (9f approximately 13f) with 2-hydroxyimino-2-(3-hydroxyphenyl)acetyl group at the 7-position of a cephem nucleus were found to have the highest antibacterial activity against a wide-range of microorganisms, including beta-lactamase-producing bacteria. Structure-activity relationships of 2 are discussed.
摘要
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