Misra A, Visen P K, Katiyar J C
J Helminthol. 1981 Dec;55(4):273-8. doi: 10.1017/s0022149x00027875.
The chemotherapeutic responses of three test nematodes, Nippostrongylus brasiliensis, Nematospiroides dubius and Ancylostoma ceylanicum to standard antihookworm drugs were assessed in order to select a suitable host-parasite system for the primary screening of potential antihookworm compounds. N. dubius behaved inconsistently and, with some infections, required more drug to achieve 100% clearance. Nippostrongylus brasiliensis was found to be sensitive to thiabendazole, tetramisole and levamisole but the broad spectrum anthelmintic mebendazole was ineffective. A. ceylanicum was very sensitive to mebendazole, sensitive to tetramisole and levamisole and refractory to thiabendazole. In vitro, none of the compounds had any lethal effect against any of the nematodes, except mebendazole against A. ceylanicum. A. ceylanicum does occur in man and its chemotherapeutic reactions are similar to those of target hookworm infections of economic importance. As such, although not equally sensitive to standard anthelmintics, it is recommended for routine primary screening.
为了选择一个合适的宿主-寄生虫系统用于潜在抗钩虫化合物的初步筛选，评估了三种受试线虫（巴西日圆线虫、双盲肠线虫和锡兰钩口线虫）对标准抗钩虫药物的化疗反应。双盲肠线虫的表现不一致，在某些感染中，需要更多药物才能实现100%清除。发现巴西日圆线虫对噻苯达唑、四咪唑和左旋咪唑敏感，但广谱驱虫药甲苯达唑无效。锡兰钩口线虫对甲苯达唑非常敏感，对四咪唑和左旋咪唑敏感，对噻苯达唑耐药。在体外，除甲苯达唑对锡兰钩口线虫外，这些化合物对任何线虫均无致死作用。锡兰钩口线虫确实可感染人类，其化疗反应与具有经济重要性的目标钩虫感染相似。因此，尽管它对标准驱虫药并非同等敏感，但仍建议用于常规初步筛选。
