Gasc J M, Stumpf W E
J Embryol Exp Morphol. 1981 Jun;63:225-31.
Androgenic hormones induce inhibition or regression of the bursa of Fabricius in the chick embryo. The high doses of hormones necessary to this involution raises the question of the processes involved and their putative role in the normal development of the bursa. If androgens play a role it is mediated by receptor sites in target cells. Using an autoradiographic technique, receptor sites for androgenic hormones were localized in mesenchymal cells of the bursa from the primordium (7-day embryo) up to the fully differentiated immune organ (15-day embryo). No target cells containing receptor sites in their nuclei were observed in the endodermic epithelium or the follicles. Oestrogen target cells in very small number are found in the mesenchyme of the bursa, in 15-day embryos. The early presence of receptor sites for steroid hormones in the bursa of Fabricius shows that the normal development may be influenced by androgens, but the actual effects are yet to be demonstrated.
雄激素可诱导鸡胚法氏囊的抑制或退化。这种退化所需的高剂量激素引发了关于所涉及过程及其在法氏囊正常发育中假定作用的问题。如果雄激素发挥作用，它是通过靶细胞中的受体位点介导的。使用放射自显影技术，从原基（7日龄胚胎）到完全分化的免疫器官（15日龄胚胎），法氏囊中雄激素的受体位点定位于间充质细胞。在内胚层上皮或滤泡中未观察到细胞核中含有受体位点的靶细胞。在15日龄胚胎的法氏囊间充质中发现了极少数雌激素靶细胞。法氏囊中类固醇激素受体位点的早期存在表明正常发育可能受雄激素影响，但实际效果尚待证实。
