关于H1N1（A/苏联/90/77）流感病毒的起源

On the origin of the H1N1 (A/USSR/90/77) influenza virus.

作者信息

Kozlov J V, Gorbulev V G, Kurmanova A G, Bayev A A, Shilov A A, Zhdanov V M

出版信息

J Gen Virol. 1981 Oct;56(Pt 2):437-40. doi: 10.1099/0022-1317-56-2-437.

Abstract

The influenza virus H1N1 (the A/USSR/90/77 strain) that reappeared in 1977 after the H1N1 influenza viruses had disappeared from the human population, is compared with the A/FM/1/47 and the A/FW/1/50 influenza viruses by the method of oligonucleotide mapping of individual segments of the viral RNAs. Seven genes of the A/USSR/90/77 virus appear to be very similar to the corresponding genes of the A/FW/1/50 virus, whereas the gene coding for the M protein displays considerable homology to the corresponding gene of the A/FM/1/47 virus. The data demonstrate that the A/USSR/90/77 strain is a recombinant virus.

摘要

1977年重新出现的甲型流感病毒H1N1（A/USSR/90/77毒株），是在H1N1流感病毒已从人群中消失之后出现的。通过对病毒RNA各个片段进行寡核苷酸图谱分析的方法，将其与A/FM/1/47和A/FW/1/50流感病毒进行了比较。A/USSR/90/77病毒的七个基因似乎与A/FW/1/50病毒的相应基因非常相似，而编码M蛋白的基因与A/FM/1/47病毒的相应基因显示出相当高的同源性。数据表明，A/USSR/90/77毒株是一种重组病毒。