Reynolds L K, Ho H P, Taper L J
J Nutr. 1984 Dec;114(12):2247-55. doi: 10.1093/jn/114.12.2247.
The effects of 15, 30 or 50% caloric restriction during pregnancy on maternal and fetal compartments was determined in obese Sprague-Dawley rats. Pregnant and nonpregnant animals were assigned on a weight basis to one of the dietary treatments. All nutrients, except calories, were fed at levels to meet dietary requirements. Animals were killed on day 20 of treatment and fetuses were taken by Caesarian section. Pregnant animals achieved positive weight gain during 20 days of gestation at all levels of caloric restriction. Nonpregnant animals lost body weight when calories were restricted by 30 and 50%. Number of fetuses, fetal body nitrogen, and pup weight were not statistically different (P less than 0.05) among groups. Animals fed the 30 and 50% calorie-restricted diets showed a significant (P less than 0.05) decrease in total-body fat. Percent carcass protein tended to increase as dietary caloric restriction increased. The fetal compartment was apparently not affected by maternal caloric restriction up to 50% during pregnancy provided that all other nutrients were supplied in adequate amounts. Maternal stores were adversely affected at levels of 30 and 50% caloric restriction.
在肥胖的斯普拉格-道利大鼠中，确定了孕期15%、30%或50%的热量限制对母体和胎儿部分的影响。怀孕和未怀孕的动物根据体重被分配到一种饮食处理组。除热量外，所有营养素的喂养水平均满足饮食需求。在处理的第20天处死动物，并通过剖腹产取出胎儿。在所有热量限制水平下，怀孕动物在20天的妊娠期内体重均实现了正向增加。当热量限制30%和50%时，未怀孕动物体重减轻。各组之间的胎儿数量、胎儿身体氮含量和幼崽体重无统计学差异（P<0.05）。喂食30%和50%热量限制饮食的动物全身脂肪显著减少（P<0.05）。随着饮食热量限制的增加，胴体蛋白百分比趋于上升。如果所有其他营养素供应充足，孕期高达50%的母体热量限制显然不会影响胎儿部分。在30%和50%的热量限制水平下，母体储备受到不利影响。
