Buxton D, Miller H R, Finlayson J, Wallace G R
J Med Microbiol. 1981 Nov;14(4):435-42. doi: 10.1099/00222615-14-4-435.
Four non-immune sheep and two with naturally acquired antibody were inoculated subcutaneously in the lower part of the leg with 100 cysts of Toxoplasma gondii. Two other non-immune sheep were given a control inoculum. Efferent lymph from the popliteal nodes on the side of the injection was collected via a cannula and injected into mice. Live toxoplasms were present in the lymph of non-immune sheep from day 2 until day 15, at which time the experiment was terminated. Corresponding samples of lymph from the one immune animal tested were almost always negative. Severe pathological changes were present in lymph nodes from non-immune sheep. Gross enlargement, loss of architecture, haemorrhages, and some necrosis occurred, and the sinuses were packed with plasma cells and plasmablasts. Changes in the nodes of immune sheep were similar but less striking, with retention of architecture, no haemorrhages and no necrosis. It was concluded that the lymphadenopathy in sheep is similar to that in rabbits, mice and man with toxoplasmosis.
给4只无免疫力的绵羊和2只有自然获得性抗体的绵羊在小腿下部皮下接种100个刚地弓形虫包囊。给另外2只无免疫力的绵羊接种对照接种物。通过插管收集注射侧腘淋巴结的输出淋巴并注入小鼠体内。在第2天至第15天，无免疫力绵羊的淋巴中存在活的弓形虫，此时实验终止。所检测的1只免疫动物的相应淋巴样本几乎总是呈阴性。无免疫力绵羊的淋巴结出现严重病理变化。出现明显肿大、结构破坏、出血和一些坏死，窦内充满浆细胞和成浆细胞。免疫绵羊淋巴结的变化相似但不那么明显，结构保留，无出血和坏死。得出的结论是，绵羊的淋巴结病与兔、小鼠和人类弓形虫病的淋巴结病相似。
