Lazarus H M, Herzig R H, Bornstein R, Laipply T C
J Natl Med Assoc. 1980 Dec;72(12):1196-9.
Sunlight induced squamous cell carcinoma of the skin is common and produces low incidence of metastases. Non-actinic squamous cell carcinoma, however, possesses a metastatic potential even when well differentiated. A representative case of keratinizing squamous cell carcinoma arising in a lower extremity with development of widespread metastases is discussed. The prognostic factors associated with metastasizing de novo squamous cell carcinoma of the extremity include: site of origin, duration of lesion, degree of differentiation, sex of patient, and size of the primary lesion. Organs prone to metastasis include: regional lymph nodes, liver, lungs, and bone. As skin cancers of this variety metastasize, the clinician must recognize this potential when considering therapeutic strategy.
阳光诱导的皮肤鳞状细胞癌很常见，转移发生率低。然而，非光化性鳞状细胞癌即使分化良好也具有转移潜能。本文讨论了一例发生于下肢的角化性鳞状细胞癌并伴有广泛转移的典型病例。与肢体原发性鳞状细胞癌转移相关的预后因素包括：起源部位、病变持续时间、分化程度、患者性别以及原发病变大小。易于转移的器官包括：区域淋巴结、肝脏、肺和骨。由于这种类型的皮肤癌会发生转移，临床医生在考虑治疗策略时必须认识到这种可能性。
