Josiah Andrea Jess, Twilley Danielle, Pillai Sreejarani Kesavan, Ray Suprakas Sinha, Lall Namrita
DST-CSIR National Centre for Nanostructured Materials, Council for Scientific and Industrial Research, Pretoria 0001, South Africa.
Department of Chemical Sciences, University of Johannesburg, Doornfontein 2028, South Africa.
Molecules. 2021 Apr 1;26(7):1979. doi: 10.3390/molecules26071979.
Keratinocyte carcinoma (KC) is a form of skin cancer that develops in keratinocytes, which are the predominant cells present in the epidermis layer of the skin. Keratinocyte carcinoma comprises two sub-types, namely basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). This review provides a holistic literature assessment of the origin, diagnosis methods, contributing factors, and current topical treatments of KC. Additionally, it explores the increase in KC cases that occurred globally over the past ten years. One of the principal concepts highlighted in this article is the adverse effects linked to conventional treatment methods of KC and how novel treatment strategies that combine phytochemistry and transdermal drug delivery systems offer an alternative approach for treatment. However, more in vitro and in vivo studies are required to fully assess the efficacy, mechanism of action, and safety profile of these phytochemical based transdermal chemotherapeutics.
角质形成细胞癌（KC）是一种在角质形成细胞中发生的皮肤癌，角质形成细胞是皮肤表皮层中的主要细胞。角质形成细胞癌包括两种亚型，即基底细胞癌（BCC）和鳞状细胞癌（SCC）。本综述提供了对角质形成细胞癌的起源、诊断方法、促成因素和当前局部治疗的全面文献评估。此外，还探讨了过去十年全球范围内角质形成细胞癌病例的增加情况。本文强调的一个主要概念是与角质形成细胞癌传统治疗方法相关的不良反应，以及将植物化学和透皮给药系统相结合的新型治疗策略如何提供一种替代治疗方法。然而，需要更多的体外和体内研究来全面评估这些基于植物化学的透皮化疗药物的疗效、作用机制和安全性。
