[Experimental prophylactic and prospective epidemiological studies of ischemic heart disease in Kaunas].

The authors report on the data of two epidemiological investigations of ischaemic heart disease (IHD) that were undertaken in Kaunas (Kaunas-Rotterdam Intervention Study 1972 - 1974) to study the efficacy of the multifactorial prevention of IHD. The comparison of the screening data of representative selections in men 45-59 years no significant spread of IHD and its risk factors have been found. On the strength of the data of prospective observation of selection of the first investigation a statistically significant relationship between the risk factors and the spread of the stenosing atherosclerosis in the coronaries have been recorded. A nomogram for the determination of the individual risk of IHD development has been constructed. The analysis of the results of the 2nd investigation showed that the active effect at the level of the factors of risk, in the first place by nonmedicinal agents, helps their significant decrease.