O'Neil R M, Ashack R J, Goodman F R
J Pharmacol Methods. 1981 May;5(3):267-73. doi: 10.1016/0160-5402(81)90094-2.
Respiratory responses to a variety of known bronchoactive agents were compared in anesthetized rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) monkeys. Administration of 0.1 to 1.0% histamine aerosols resulted in an increase in airway resistance of 50 to 200% and a decrease in lung compliance of 30 to 80%. Aerosols of prostaglandin E2 (1 mg/ml), terbutaline (10 mg/ml), and isoproterenol (10 mg/ml) or iv aminophylline (up to 7.0 mg/kg) administered concomitantly with histamine produced a transient reversal of the histamine-induced changes in both species. Since the rhesus and cynomolgus monkeys responded in a comparable manner to these bronchodilator agents, the cynomolgus monkey appears to be an additional valuable model for the evaluation of potential bronchoactive compounds.
在麻醉的恒河猴（猕猴属）和食蟹猴（食蟹猕猴）中比较了对多种已知支气管活性剂的呼吸反应。给予0.1%至1.0%的组胺气雾剂导致气道阻力增加50%至200%，肺顺应性降低30%至80%。与组胺同时给予前列腺素E2（1毫克/毫升）、特布他林（10毫克/毫升）、异丙肾上腺素（10毫克/毫升）气雾剂或静脉注射氨茶碱（高达7.0毫克/千克）可使两种动物组胺诱导的变化产生短暂逆转。由于恒河猴和食蟹猴对这些支气管扩张剂的反应方式相似，食蟹猴似乎是评估潜在支气管活性化合物的另一个有价值的模型。
