Thal L J, Rosen W, Sharpless N S, Crystal H
Neurobiol Aging. 1981 Fall;2(3):205-8. doi: 10.1016/0197-4580(81)90022-1.
Seven mildly to moderately demented patients with Alzheimer's disease were treated with either placebo or choline chloride (50, 100 and 200 mg/kg/24 hrs) in a double blind, crossover study. Detailed psychometric analysis was carried out at the end of each two-week period of drug or placebo administration. No subjects showed significant overall improvement at any dose level despite more than a doubling of the baseline plasma choline level.
在一项双盲交叉研究中，对7名患有阿尔茨海默病且痴呆程度为轻度至中度的患者，给予安慰剂或氯化胆碱（50、100和200毫克/千克/24小时）进行治疗。在每两周的药物或安慰剂给药期结束时进行详细的心理测量分析。尽管基线血浆胆碱水平增加了一倍多，但在任何剂量水平下，均无受试者表现出显著的整体改善。
