Wernet D, Klein J
Prog Clin Biol Res. 1981;66 Pt A:573-7.
Eight H-2K/D identical congenic strain combinations were tested in cell-mediated lympholysis. The reaction pattern of selected mouse strains revealed unidirectional reactivity to Tla-linked antigens in six strain combinations, whereas in two strain combinations the loci coding for the target antigen could only tentatively be linked to H-2. The Tla-linked loci defined by the different strain combinations appear to be identical with the H-2T (Qa-1) locus. Typing of B10.W lines for the H-2T (Qa-1) locus revealed the presence of alleles that appear to be the same as those present in inbred strains, as well as alleles that are different from the inbred-defined alleles but that share some determinants with the latter. The H-2T (Qa-1) system thus appears to consist of a limited number of alleles, some of which are closely related and presumably similar in their genetic structure.
在细胞介导的淋巴细胞溶解试验中对8种H-2K/D相同的同类系组合进行了测试。所选小鼠品系的反应模式显示，在6种品系组合中对Tla连锁抗原具有单向反应性，而在2种品系组合中，编码靶抗原的基因座只能暂时与H-2连锁。由不同品系组合定义的Tla连锁基因座似乎与H-2T（Qa-1）基因座相同。对B10.W系进行H-2T（Qa-1）基因座分型，结果显示存在与近交系中相同的等位基因，以及与近交系定义的等位基因不同但与后者共享一些决定簇的等位基因。因此，H-2T（Qa-1）系统似乎由数量有限的等位基因组成，其中一些等位基因密切相关，其遗传结构可能相似。
