Blandova Z K, Egorov I K
Genetika. 1975;10(8):171-3.
The differences in the H-2 system between mice of the C57BL/10 (H-2b) and 129 (H-2bc) were studied in crosses B10.D (H-2d) or recombinant strains R106 (KbSbDda), R107 (KbSbDd) and R101 (KdSdDb) with strains 129 or B10.129 (6M). Most skin grafts from the strain C57BL/10 were rapidly rejected in the F1 hybrids derived from the crosses with strains B10.D2, R106 and R107, thus indicating to the effect of the relatively strong H-locus either in the D region or in the Tla region of H-2b. Chronic responses were observed in the F1 hybrids derived from crosses with the strains R101 and R103, indicating to the weak effect of another locus. However all the skin grafts survived in the F1 hybrids with the strain HTG (KdSdDb). This weak H gene is apparently located to the left of the crossover in the recombinants R101 and R103, but to the right of the crossover in the HTG, i. e. between the loci Slp and H-2D. The new locus is tentatively designated as H-2W.
在与129品系或B10.129（6M）品系杂交的B10.D（H-2d）或重组品系R106（KbSbDda）、R107（KbSbDd）和R101（KdSdDb）中，研究了C57BL/10（H-2b）和129（H-2bc）小鼠之间H-2系统的差异。来自C57BL/10品系的大多数皮肤移植物在与B10.D2、R106和R107品系杂交产生的F1杂种中迅速被排斥，这表明H-2b的D区或Tla区中相对较强的H基因座具有作用。在与R101和R103品系杂交产生的F1杂种中观察到慢性反应，这表明另一个基因座的作用较弱。然而，所有皮肤移植物在与HTG（KdSdDb）品系的F1杂种中都存活了下来。这个弱H基因显然位于重组体R101和R103的交叉点左侧，但位于HTG的交叉点右侧，即在Slp和H-2D基因座之间。这个新基因座暂时命名为H-2W。
