Olds M E, Fobes J L
Pharmacol Biochem Behav. 1981 Aug;15(2):167-71. doi: 10.1016/0091-3057(81)90172-6.
The catecholaminergic basis of the stimulant actions of amphetamine and morphine was investigated in adult rats treated neonatally with 6-hydroxydopamine (6-OHDA) to produce depletion of cortical catecholamines and marked elevation of norepinephrine in the pons. On days 3, 5, 7 and 9 after birth, rat pups were injected bilaterally in the lateral ventricles with 100, 200, or 400 micrograms of 6-OHDA, dissolved in artificial cerebrospinal fluid (CSF). A control group was injected with the CSF vehicle. The capacity of amphetamine (2 mg/kg) and morphine (1.25, 2.5, and 3.5 mg/kg) to produce behavioral stimulant effects was then subsequently tested in adults. The stimulant effect of amphetamine was attenuated in animals pretreated with 100 and 200 micrograms 6-OHDA and was blocked in those treated with 400 micrograms 6-OHDA. The stimulant effects obtained with morphine were blocked by all 6-OHDA doses (100 and 200 micrograms). For morphine, no tests were made in the 400 micrograms 6-OHDA group on the basis of results obtained in animals pretreated with the lower doses of 6-OHDA. These results are discussed in terms of differing roles played by the catecholamine systems in the production of behavioral stimulation.
在新生期用6-羟基多巴胺（6-OHDA）处理以耗尽皮质儿茶酚胺并使脑桥中去甲肾上腺素显著升高的成年大鼠中，研究了苯丙胺和吗啡兴奋作用的儿茶酚胺能基础。在出生后第3、5、7和9天，给幼鼠双侧侧脑室注射溶解于人工脑脊液（CSF）中的100、200或400微克6-OHDA。对照组注射CSF溶媒。随后在成年大鼠中测试苯丙胺（2毫克/千克）和吗啡（1.25、2.5和3.5毫克/千克）产生行为兴奋作用的能力。在用100和200微克6-OHDA预处理的动物中，苯丙胺的兴奋作用减弱，在用400微克6-OHDA处理的动物中则被阻断。吗啡产生的兴奋作用被所有剂量的6-OHDA（100和200微克）阻断。对于吗啡，基于用较低剂量6-OHDA预处理的动物所获得的结果，未对400微克6-OHDA组进行测试。根据儿茶酚胺系统在行为兴奋产生中所起的不同作用对这些结果进行了讨论。
