Gerhardt S, Liebman J M
Pharmacol Biochem Behav. 1981 Nov;15(5):767-71. doi: 10.1016/0091-3057(81)90020-4.
To assess the possibility of dissociating drug-induced gross performance deficits from effects on brain stimulation reward, the nose-poke and bar-press operants were systematically compared. Pentobarbital and methocarbamol (a muscle relaxant) reduced bar-pressing more strongly than nose-poking. In contrast, clonidine and haloperidol, which disrupt noradrenergic and dopaminergic neurotransmission respectively, had no differential effect on these operants. The nose-poke operant appears less vulnerable to drug-induced gross motor impairment and may be more suitable for pharmacological studies of self-stimulation.
为了评估将药物诱导的总体行为缺陷与对脑刺激奖赏的影响相分离的可能性，对鼻触和压杆操作进行了系统比较。戊巴比妥和甲氯芬那酸（一种肌肉松弛剂）对压杆的抑制作用比对鼻触的抑制作用更强。相比之下，分别破坏去甲肾上腺素能和多巴胺能神经传递的可乐定和氟哌啶醇，对这些操作没有差异影响。鼻触操作似乎较不易受到药物诱导的总体运动损伤的影响，可能更适合用于自我刺激的药理学研究。
