Fantie B D, Nakajima S
Dalhousie University, Halifax, Nova Scotia, Canada.
Behav Neurosci. 1987 Oct;101(5):626-33. doi: 10.1037//0735-7044.101.5.626.
Dopaminergic blocking agents have been known to suppress intracranial self-stimulation, but whether the suppression results from a reduction in the rewarding value of stimulation or from motor deficits has remained controversial. We have resolved this controversy by developing an operant technique minimally dependent on motor activity: Rats were trained to perform a bar-holding response for 3s or to produce hippocampal theta waves for 3s when the bar was retracted. Decamethonium bromide (a muscle relaxant) reduced bar holding without affecting theta production for brain stimulation. Pimozide (a dopaminergic blocking-agent) reduced both bar holding and theta production for stimulation, though rats were still capable of making the theta response at a rate comparable to the preinjection rate. Dopaminergic blocking at low doses reduces the rewarding value of brain stimulation at the level of the lateral hypothalamus. The method described in this report has wide applicability.
已知多巴胺能阻断剂可抑制颅内自我刺激，但这种抑制是由于刺激的奖赏价值降低还是运动缺陷所致，一直存在争议。我们通过开发一种对运动活动依赖性最小的操作性技术解决了这一争议：训练大鼠在横杆缩回时进行3秒的握杆反应或产生3秒的海马θ波。溴化十烃季铵（一种肌肉松弛剂）减少了握杆行为，而不影响脑刺激产生的θ波。匹莫齐特（一种多巴胺能阻断剂）减少了刺激引起的握杆和θ波产生，尽管大鼠仍能以与注射前速率相当的速率做出θ波反应。低剂量的多巴胺能阻断会降低下丘脑外侧水平脑刺激的奖赏价值。本报告中描述的方法具有广泛的适用性。
