Dahlager J I
J Nucl Med. 1978 Dec;19(12):1324-30.
Serial renography with [125I]-o-iodohippurate was performed in 42 rabbits after temporary clamping of the renal artery for 1--3 hr and contralateral nephrectomy. Renograms were done before and after warm ischemia and followed 2, 4, 6, and 14 days after restoration of circulation. Correlation was found between duration of ischemia and severity of postischemic renographic changes. Most sensitive was the third phase, which showed distortion after 1 hr of ischemia; the second phase decreased after 2 1/2 hours of ischemia. The profound changes seen on the second day were shown to be due to further damage of the tubular cell system after restored flow. In vitro [125I]-o-iodohippurate uptake in cortex slices showed a significant decrease after warm ischemia damage and 48 hours restored flow. The second phase recovered more rapidly than the excretory function.
对42只兔子在肾动脉暂时夹闭1至3小时并进行对侧肾切除术后，用[125I]-邻碘马尿酸进行了系列肾图检查。在热缺血前后进行肾图检查，并在恢复循环后第2、4、6和14天进行随访。发现缺血持续时间与缺血后肾图变化的严重程度之间存在相关性。最敏感的是第三期，缺血1小时后即出现变形；第二期在缺血2.5小时后降低。第二天出现的深刻变化表明是由于恢复血流后肾小管细胞系统进一步受损所致。热缺血损伤和恢复血流48小时后，皮质切片中[125I]-邻碘马尿酸的体外摄取显著降低。第二期的恢复比排泄功能更快。
