Bazin M, Turcotte H, Lagacé R, Boutet M
Rev Can Biol. 1981 Sep;40(3):263-76.
The permeability of aortic endothelium and myocardial capillaries was examined in 72 Sprague-Dawley rats (approximately 350 g) using the diffusion tracer peroxidase. Animals were subjected to cigarette smoke for periods of 1 day (acute effects), 2 weeks (sub-acute effects) and 15 weeks (chronic effects) and were sacrificed 5 minutes or 8 hours after smoking. Peroxidase was not generally present at the sub-endothelial level in the aortic endothelium of control animals and sham-smokers. However, in smokers, the increase in peroxidase permeability is proportional to the smoking period. Moreover, in these smokers we observed junctional and subendothelial vacuolar dilatations which correspond to degenerative morphologic changes. Cigarette smoke has a different effect on the right ventricle. Endothelial permeability of the myocardial capillaries increases in animals subjected to cigarette smoke for 1 day and those who smoked for 2 weeks sacrificed 5 minutes after smoking. This increase in permeability is not related to the significant morphologic changes observed in the myocardium and endothelial capillaries. However, the myocardial endothelial capillaries, the sub-endothelial space and the adjacent interstitial space were generally free of peroxidase in animals subjected to cigarette smoke for 15 weeks and in those smoking for 2 weeks sacrificed 8 hours later. An adaptive phenomenon to the effects of cigarette smoke appear to exist in the myocardial endothelium capillaries contrary to that which is observed in the thoracic aorta.
使用扩散示踪剂过氧化物酶对72只体重约350克的斯普拉格-道利大鼠的主动脉内皮和心肌毛细血管通透性进行了检测。将动物暴露于香烟烟雾中1天（急性效应）、2周（亚急性效应）和15周（慢性效应），并在吸烟后5分钟或8小时处死。在对照动物和假吸烟者的主动脉内皮中，过氧化物酶一般不存在于内皮下层。然而，在吸烟者中，过氧化物酶通透性的增加与吸烟时间成正比。此外，在这些吸烟者中，我们观察到连接和内皮下空泡扩张，这与退行性形态学变化相对应。香烟烟雾对右心室有不同的影响。在暴露于香烟烟雾1天的动物和吸烟2周后5分钟处死的动物中，心肌毛细血管的内皮通透性增加。这种通透性的增加与在心肌和内皮毛细血管中观察到的显著形态学变化无关。然而，在暴露于香烟烟雾15周的动物和吸烟2周后8小时处死的动物中，心肌内皮毛细血管、内皮下层空间和相邻的间质空间一般没有过氧化物酶。与胸主动脉中观察到的情况相反，心肌内皮毛细血管中似乎存在对香烟烟雾影响的适应性现象。
