Baldy-Moulinier M, Besset A, Calvet B, Michel H
Rev Electroencephalogr Neurophysiol Clin. 1981 Sep;11(1):123-32. doi: 10.1016/s0370-4475(81)80043-3.
24 h sleep-waking EEG records of 23 patients with hepatic cirrhosis, 18 having hepatic encephalopathy, were studied. Comparison with a group of normal controls showed an increase in diurnal somnolence (08 h-22 h) and nocturnal waking (22 h-08 h) in all the patients. There was a significant reduction in the longest duration of waking and uninterrupted sleep periods in the patients with cirrhosis. Triphasic waves (characteristic of hepatic encephalopathy) were usually increased during waking and reduced in sleep. The factors involved in this disturbance of sleep-waking patterns in hepatic encephalopathy are discussed (cerebral monoamines, false neurotransmitters, cerebral arteriovenous shunts...).
对23例肝硬化患者（其中18例患有肝性脑病）进行了24小时睡眠-清醒脑电图记录研究。与一组正常对照者相比，所有患者的日间嗜睡（08:00-22:00）和夜间觉醒（22:00-08:00）均有所增加。肝硬化患者清醒和不间断睡眠的最长持续时间显著缩短。三相波（肝性脑病的特征性表现）通常在清醒时增加，在睡眠时减少。本文讨论了肝性脑病中这种睡眠-清醒模式紊乱所涉及的因素（脑单胺类物质、假性神经递质、脑动静脉分流等）。
