Allegra L, Bossi R, Braga P C
Respiration. 1981;42(2):105-9. doi: 10.1159/000194412.
Some pharmacological properties of Sobrerol have been assessed, in frog palate preparation, by measuring the mucociliary transport velocity due to mucus samples obtained for patients suffering from chronic bronchial inflammatory diseases characterized by dense bronchial secretions. The patients were studied before and after 4 days of treatment with Sobrerol, 600 mg per day per os. The significant increase in the relative ratio of mucociliary transport of mucus of treated patients, together with evidence coming from previous experiments, indicates that this drug is capable of modifying rheological properties of bronchial secretions, in such patients, through an "in-vivo' muco-regulating activity, thus facilitating mucociliary clearance.
在青蛙腭部制备实验中，通过测量慢性支气管炎性疾病患者（其特征为支气管分泌物浓稠）的黏液样本所导致的黏液纤毛转运速度，对索布瑞醇的一些药理特性进行了评估。这些患者在接受每日口服600毫克索布瑞醇治疗4天之前和之后接受了研究。治疗患者黏液纤毛转运相对比率的显著增加，以及先前实验的证据表明，这种药物能够通过“体内”黏液调节活性改变此类患者支气管分泌物的流变学特性，从而促进黏液纤毛清除。
