Clavijo F, Krahenbuhl B
Schweiz Med Wochenschr. 1981 Dec 19;111(51):2023-7.
136 patients suffering from Raynaud's phenomenon have been observed for 3.9 years and information has been collected by a questionnaire sent to 142 patients (136 answers: 96%). An improvement was noticed by 36% of these patients, steady state by 48%, and worsening in 16%. Among 25 patients suffering from idiopathic Raynaud's disease, 25% improved and 12% worsened. Among 12 patients suffering from scleroderma, 7 worsened (4 deaths) and there was no improvement in the others. In patients suffering from secondary Raynaud's phenomenon, no systemic disease appeared during the follow-up period. The profile of Raynaud's phenomenon which is going to worsen is characterized by an abnormal Allen test, digital necrosis, age over 60 years and Raynaud's disease of more than 1 year's standing.
对136例患有雷诺现象的患者进行了3.9年的观察，并通过向142例患者发送问卷（136份回复：96%）收集了信息。这些患者中36%有改善，48%处于稳定状态，16%病情恶化。在25例患有特发性雷诺病的患者中，25%有所改善，12%病情恶化。在12例患有硬皮病的患者中，7例病情恶化（4例死亡），其他患者无改善。在患有继发性雷诺现象的患者中，随访期间未出现全身性疾病。病情将恶化的雷诺现象的特征为艾伦试验异常、手指坏死、年龄超过60岁以及病程超过1年的雷诺病。
