Neviackas J A, Bauer J H
South Med J. 1981 Dec;74(12):1457-60. doi: 10.1097/00007611-198112000-00011.
To assess renal function changes induced by marathon racing in asymptomatic runners, we studied them before, six hours after, and one week after warm and cold weather marathons (26.2 miles [42 km]). Standard serum electrolytes, creatine phosphokinase (CPK), urinalysis, urinary myoglobin, and renal function tests (para-aminohippurate [PAH], inulin, and true creatinine clearances) were performed. After rehydration to their prerace weight, the subjects showed no postrace change in serum electrolytes. The CPK rose postrace and was two to three times higher in the warm weather runners than in the cold weather runners. All postrace urinalyses were grossly abnormal. Urinary myoglobins were positive postrace in warm weather runners and negative in cold weather runners. Warm weather runners showed a 50% decline in inulin clearance postrace but maintained PAH clearance. At one week, inulin clearance returned to baseline but fractional excretion of creatinine was below unity. In contrast, cold weather runners showed no change in inulin and PAH clearances postrace or at one week, but fractional excretion or creatinine postrace was less than unity returning to baseline at one week. We conclude that renal function abnormalities occur in marathon runners and that the severity of the abnormality is temperature-dependent.
为评估无症状跑步者马拉松比赛引起的肾功能变化，我们在温暖天气马拉松和寒冷天气马拉松（26.2英里[42公里]）之前、之后6小时以及之后1周对他们进行了研究。进行了标准血清电解质、肌酸磷酸激酶（CPK）、尿液分析、尿肌红蛋白和肾功能测试（对氨基马尿酸[PAH]、菊粉和真肌酐清除率）。补液至赛前体重后，受试者血清电解质赛后无变化。CPK赛后升高，温暖天气跑步者的CPK比寒冷天气跑步者高两到三倍。所有赛后尿液分析均明显异常。温暖天气跑步者赛后尿肌红蛋白呈阳性，寒冷天气跑步者呈阴性。温暖天气跑步者赛后菊粉清除率下降50%，但PAH清除率保持不变。1周时，菊粉清除率恢复至基线，但肌酐分数排泄低于1。相比之下，寒冷天气跑步者赛后及1周时菊粉和PAH清除率无变化，但赛后肌酐分数排泄小于1，1周时恢复至基线。我们得出结论，马拉松跑步者会出现肾功能异常，且异常的严重程度与温度有关。
