Nemoto R, Mori H, Iwata K, Kato T, Harada M
Tohoku J Exp Med. 1981 Jul;134(3):257-63. doi: 10.1620/tjem.134.257.
We attempted to produce a malignant urinary bladder tumor in rabbits by transplanting tumor cells. Each of 51 male mixed-bred rabbits received 0.3 ml V2 carcinoma cell suspension. The transplantation was done after laparotomy via injection into the bladder wall. Within 2 weeks malignant tumors were observed in the bladder. Without any manipulation to the mucosa, all of the tumors were led to exulceration into the bladder lumen. The incidence of malignant tumor reached 96 per cent. Metastases in these animals were seen in the lungs and para-aortic lymph nodes. This malignant tumor model seems especially suitable for the study of new methods of transurethral treatment of bladder cancer.
我们试图通过移植肿瘤细胞在兔体内产生恶性膀胱肿瘤。51只雄性杂种兔每只接受0.3 ml V2癌细胞悬液。移植在剖腹术后通过注入膀胱壁进行。2周内膀胱内观察到恶性肿瘤。在未对黏膜进行任何操作的情况下，所有肿瘤均破溃进入膀胱腔。恶性肿瘤的发生率达到96%。这些动物出现了肺和主动脉旁淋巴结转移。这种恶性肿瘤模型似乎特别适合用于研究膀胱癌经尿道治疗的新方法。
