体内药物分布的数学预测：多柔比星在大鼠体内的研究
Mathematical prediction of drug distribution in vivo: studies with doxantrazole in rats.
作者信息
Caldwell I C, Mahmood S, Weatherall M
出版信息
J Pharmacokinet Biopharm. 1978 Dec;6(6):521-37. doi: 10.1007/BF01062107.
PMID:731415
Abstract
A pharmacokinetic model incorporating 14 compartments and 29 transfer coefficients has been developed from experimental data obtained after intravenous administration of a single dose to describe the distribution of doxantrazole in the rate. The distribution calculated from the model agreed closely with that determined experimentally. In addition, the model was able to predict with considerable accuracy the distribution of doxantrazole after repeated dosing.
摘要
一个包含14个房室和29个转运系数的药代动力学模型，是根据单次静脉给药后获得的实验数据建立的，用于描述多柔比星在体内的分布情况。该模型计算得出的分布情况与实验测定结果高度吻合。此外，该模型能够以相当高的准确度预测多次给药后多柔比星的分布情况。
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