Kakizoe T, Tobisu K, Mizutani T, Tsutsumi M, Tanaka Y, Sakamoto M
Urology Division, National Cancer Center Hospital, Tokyo.
Jpn J Cancer Res. 1992 Dec;83(12):1354-8. doi: 10.1111/j.1349-7006.1992.tb02769.x.
Eighty cases of cystectomized and step-sectioned pT1 transitional cell carcinomas of various grades were analyzed. During the same period, 30 consecutive cases of pT2 carcinomas were also cystectomized and examined for comparison. This is a cross-sectional study of a variety of cases of bladder cancer, designed to delineate the characteristics of G3.pT1 disease. Tumors in this series had a full set of various pathological findings; grades 1 to 3, stages Ta-T1-T2, papillary-papillonodular-nodular tumor configuration, alpha-beta-gamma type of invasion, presence of lymphatic and venous involvement, and presence of associated carcinoma in situ/dysplasia. There is a distinct tendency of stepwise disease progression, such as grade 1-->3, stage T1-->T2, papillary-->nodular configuration, and alpha-->gamma invasion, these factors being mutually related. We noted a similarity between tumor groups containing G3 component, such as G2-3.pT1, G3 > 2.pT1, G3.pT1, G1-3.pT2, and G3.pT2. These tumors are different from groups such as G1-2.pT1, G2.pT1 and G2 > 3.pT1 in terms of tumor configuration and type of invasion. As regards pT1 having G3 components, early cystectomy seems to be the surest treatment. Whenever one adopts a conservative policy in treatment of these tumors, extreme care should be taken to monitor tumor progression.
对80例经膀胱切除及连续切片的不同分级的pT1期移行细胞癌进行了分析。同期，还对30例连续的pT2期癌进行了膀胱切除及检查以作比较。这是一项对各种膀胱癌病例的横断面研究，旨在描述G3.pT1疾病的特征。该系列中的肿瘤具有全套各种病理表现；1至3级，Ta-T1-T2期，乳头状-乳头结节状-结节状肿瘤形态，α-β-γ型浸润，存在淋巴管和静脉受累，以及存在相关的原位癌/发育异常。存在明显的疾病逐步进展趋势，如1级→3级，T1期→T2期，乳头状→结节状形态，以及α→γ浸润，这些因素相互关联。我们注意到含有G3成分的肿瘤组之间存在相似性，如G2-3.pT1、G3＞2.pT1、G3.pT1、G1-3.pT2和G3.pT2。这些肿瘤在肿瘤形态和浸润类型方面与G1-2.pT1、G2.pT1和G2＞3.pT1等组不同。对于具有G3成分的pT1期肿瘤，早期膀胱切除术似乎是最可靠的治疗方法。每当对这些肿瘤采取保守治疗策略时，应极其小心地监测肿瘤进展。
