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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Brittebo E, Löftberg B

Xenobiotica. 1981 Sep;11(9):619-25. doi: 10.3109/00498258109045873.

By the use of whole-body autoradiography, the localization of N-nitroso[14C]pyrrolidine and its metabolites was demonstrated in the tissues of C57B1-mice and Sprague-Dawley rats. 2. On the basis of the autoradiographic data, tissues were selected and tested for their ability to metabolize N-nitroso[14C]pyrrolidinie to 14CO2 and tissue-bound metabolites. 3. The results indicated that only few tissues had a marked ability to degrade N-nitrosopyrrolidine. These were the liver and the nasal mucosa in both species, the tracheobronchial mucosa in mice, and to a lower extent the kidneys in both species.

通过全身放射自显影技术，在C57B1小鼠和Sprague-Dawley大鼠的组织中证实了N-亚硝基[14C]吡咯烷及其代谢产物的定位。2. 根据放射自显影数据，选择组织并测试其将N-亚硝基[14C]吡咯烷代谢为14CO2和组织结合代谢产物的能力。3. 结果表明，只有少数组织具有显著降解N-亚硝基吡咯烷的能力。这些组织在两个物种中都是肝脏和鼻黏膜，在小鼠中是气管支气管黏膜，在两个物种中肾脏的降解能力较低。

Brittebo E, Löftberg B

Xenobiotica. 1981 Sep;11(9):619-25. doi: 10.3109/00498258109045873.

By the use of whole-body autoradiography, the localization of N-nitroso[14C]pyrrolidine and its metabolites was demonstrated in the tissues of C57B1-mice and Sprague-Dawley rats. 2. On the basis of the autoradiographic data, tissues were selected and tested for their ability to metabolize N-nitroso[14C]pyrrolidinie to 14CO2 and tissue-bound metabolites. 3. The results indicated that only few tissues had a marked ability to degrade N-nitrosopyrrolidine. These were the liver and the nasal mucosa in both species, the tracheobronchial mucosa in mice, and to a lower extent the kidneys in both species.

通过全身放射自显影技术，在C57B1小鼠和Sprague-Dawley大鼠的组织中证实了N-亚硝基[14C]吡咯烷及其代谢产物的定位。2. 根据放射自显影数据，选择组织并测试其将N-亚硝基[14C]吡咯烷代谢为14CO2和组织结合代谢产物的能力。3. 结果表明，只有少数组织具有显著降解N-亚硝基吡咯烷的能力。这些组织在两个物种中都是肝脏和鼻黏膜，在小鼠中是气管支气管黏膜，在两个物种中肾脏的降解能力较低。