Jensen D
Acta Neurol Scand. 1981 Sep;64(3):175-95.
In order to elucidate the parasympathetic activity of the uninhibited neurogenic bladder, controlled cystometry before and during influence of cholinergic and anticholinergic drugs has been performed on patients with normal and uninhibited neurogenic bladder. Cholinergic stimulation proved to increase the intravesical pressure to a great extent; to a higher degree in the normal than in the uninhibited bladder. In two patients with normal bladder, uninhibited detrusor contractions were induced by cholinergic stimulation. Cholinergic inhibition had only minor influence on the intravesical pressure during the filling phase. Opposite effects were obtained on the uninhibited detrusor contractions which are regarded as a part of the expulsive phase. Cholinergic stimulation increased the amplitude of the uninhibited bladder to some degree, but cholinergic inhibition markedly reduce the amplitude. Conclusively, the uninhibited neurogenic bladder is at least partly caused by an overactivity in cholinergic stimulation.
为了阐明无抑制性神经源性膀胱的副交感神经活动，对正常和无抑制性神经源性膀胱患者在胆碱能和抗胆碱能药物影响之前及期间进行了控制性膀胱测压。胆碱能刺激被证明可在很大程度上增加膀胱内压；在正常膀胱中增加的程度高于无抑制性膀胱。在两名正常膀胱患者中，胆碱能刺激诱发了无抑制性逼尿肌收缩。胆碱能抑制在充盈期对膀胱内压仅有轻微影响。对被视为排尿期一部分的无抑制性逼尿肌收缩则产生相反的效果。胆碱能刺激在一定程度上增加了无抑制性膀胱的收缩幅度，但胆碱能抑制明显降低了幅度。总之，无抑制性神经源性膀胱至少部分是由胆碱能刺激过度活跃引起的。
