Laitinen L, Miettinen A, Tikkanen I, Törnroth T, Nordling S
Clin Sci (Lond). 1985 Jul;69(1):57-62. doi: 10.1042/cs0690057.
Glomerular sialic acid was chemically measured in rats with experimental proteinuria induced by N,N'-diacetylbenzidine (DAB) or with autoimmune Heymann nephritis. In DAB nephrosis and in Heymann nephritis the relative amount of glomerular protein was increased. In DAB nephrosis the quantity of sialic acid expressed per amount of protein was decreased, but expressed per amount of DNA, which reflects the number of cells, there was no significant change. In Heymann nephritis the amount of sialic acid was not significantly altered when expressed per amount of protein or per amount of DNA. In individual animals, the amount of glomerular sialic acid expressed per amount of protein or per amount of DNA did not correlate with the severity of proteinuria. An increase in the total number of glomerular cells was found only in Heymann nephritis. The results suggest that proteinuria in the reported models is not the result of changes in glomerular sialic acid.
采用化学方法测定了用N，N'-二乙酰联苯胺（DAB）诱导实验性蛋白尿的大鼠以及患自身免疫性海曼肾炎大鼠的肾小球唾液酸含量。在DAB肾病和海曼肾炎中，肾小球蛋白的相对含量均增加。在DAB肾病中，每单位蛋白中唾液酸的含量降低，但以反映细胞数量的每单位DNA计算时，唾液酸含量无显著变化。在海曼肾炎中，以每单位蛋白或每单位DNA计算时，唾液酸含量均无显著改变。在个体动物中，每单位蛋白或每单位DNA中肾小球唾液酸的含量与蛋白尿的严重程度无关。仅在海曼肾炎中发现肾小球细胞总数增加。结果表明，所报道模型中的蛋白尿并非肾小球唾液酸变化的结果。
