Dai W S, Kuller L H, LaPorte R E, Gutai J P, Falvo-Gerard L, Caggiula A
Am J Epidemiol. 1981 Dec;114(6):804-16. doi: 10.1093/oxfordjournals.aje.a113251.
Several diseases, e.g., coronary heart disease, cancer, etc., have been related to sex hormones. Thus, research on the epidemiology of sex hormones may be productive. The epidemiologic study of testosterone has been limited due to the circadian and circannual variations and the wide interindividual variability. The authors evaluated the reliability and repeatability of a single blood draw to measure individual plasma testosterone levels in three pilot studies. The results indicated that the measurements of the hormone level are highly repeatable and a single morning specimen appeared to be sufficient for characterization of individual testosterone levels. Research then focussed on 243 men in the Multiple Risk Factor Intervention Trial to investigate the determinants of plasma testosterone level. The results indicated that age and obesity were significantly correlated with plasma testosterone level. (The multiple R of these two variables in the multiple regression analysis for plasma total testosterone was 0.32.) Smoking was positively related to testosterone through a relationship with age. Daily physical activity, history of alcohol intake, and behavior factors of A and B behavior types were not found to be related to testosterone concentrations.
几种疾病，如冠心病、癌症等，都与性激素有关。因此，对性激素流行病学的研究可能会有成果。由于昼夜节律和年度节律变化以及个体间的广泛差异，睾酮的流行病学研究受到了限制。作者在三项试点研究中评估了单次采血测量个体血浆睾酮水平的可靠性和可重复性。结果表明，激素水平的测量具有高度可重复性，单次早晨样本似乎足以表征个体睾酮水平。随后的研究聚焦于多重危险因素干预试验中的243名男性，以调查血浆睾酮水平的决定因素。结果表明，年龄和肥胖与血浆睾酮水平显著相关。（在血浆总睾酮的多元回归分析中，这两个变量的复相关系数为0.32。）吸烟通过与年龄的关系与睾酮呈正相关。未发现日常体育活动、饮酒史以及A和B行为类型的行为因素与睾酮浓度有关。
