Divers W A, Wilkes M M, Babaknia A, Hill L M, Quilligan E J, Yen S S
Am J Obstet Gynecol. 1981 Nov 15;141(6):608-10. doi: 10.1016/s0002-9378(15)33298-1.
Simultaneous determinations of amniotic fluid levels of the catecholamines dopamine (DA), norepinephrine (NE), and epinephrine (E), and the intraneuronal metabolites of DA, 3,4-dihydroxyphenylacetic acid (DOPAC) and NE, 3,4-dihydroxyphenylglycol (DOPEG), were made, by radioenzymatic assay, in pregnancies resulting in growth-retarded (n = 14) and normal (n = 63) infants. Significant elevations in the mean concentration of NE (p less than 0.000005), E (p less than 0.005), and DOPEG (p less than 0.000001) as well as a significant decrease in the mean concentration of DOPAC (p less than 0.000001) were found in pregnancies resulting in growth-retarded infants as compared to pregnancies resulting in normal infants. Amniotic fluid DOPEG levels were found to be the most discriminative. As amniotic fluid catecholamines are predominantly of fetal origin, these findings suggest that an increase in adrenergic activity and a decrease in dopaminergic activity occur in intrauterine growth retardation as a response to chronic stress.
通过放射酶分析法，对导致胎儿生长受限（n = 14）和正常（n = 63）婴儿的妊娠孕妇羊水样本中的儿茶酚胺多巴胺（DA）、去甲肾上腺素（NE）和肾上腺素（E），以及DA的神经元内代谢产物3,4-二羟基苯乙酸（DOPAC）和NE的3,4-二羟基苯乙二醇（DOPEG）水平进行了同时测定。结果发现，与导致正常婴儿的妊娠孕妇相比，导致胎儿生长受限的妊娠孕妇羊水样本中NE的平均浓度显著升高（p < 0.000005）、E显著升高（p < 0.005）、DOPEG显著升高（p < 0.000001），而DOPAC的平均浓度则显著降低（p < 0.000001）。研究发现羊水DOPEG水平的鉴别能力最强。由于羊水儿茶酚胺主要来源于胎儿，这些研究结果表明，子宫内生长受限情况下，作为对慢性应激的反应，肾上腺素能活性增加，多巴胺能活性降低。
