Kendrick J, Thompson B W, Read R C, Campbell G S, Walls R C, Casali R E
Am J Surg. 1981 Dec;142(6):739-43. doi: 10.1016/0002-9610(81)90324-x.
The clinical characteristics and course of 90 patients in whom 121 arterial emboli occurred from 1968 to 1978 were reviewed. The factor that correlated most significantly with a favorable outcome was the interval from onset of symptoms until arterial embolectomy was performed. The results of embolectomy were excellent in the patients operated on within 6 hours of symptoms (amputation rate 4 percent, mortality rate 15 percent), but less favorable in the patients operated on within 6 to 12 hours of onset of symptoms (amputation rate 27 percent, mortality 40 percent). Mortality (48 percent) and amputation (52 percent) rates in the patients operated on 12 to 48 hours after onset of symptoms were excessive. It is recommended that immediate embolectomy be performed in all potentially viable extremities in patients who present within 12 hours of symptoms, but that after 12 hours only those limbs with obvious viability (not paralyzed or anesthetic) should be operated on. Alternatives for the remainder are high dose intravenous heparinization or expedient amputation. In patients who present greater than 60 hours after the onset of symptoms, embolectomy can be performed with low morbidity and mortality.
回顾了1968年至1978年间90例发生121次动脉栓塞患者的临床特征及病程。与良好预后最显著相关的因素是从症状出现到进行动脉栓子切除术的时间间隔。在症状出现后6小时内接受手术的患者中,栓子切除术的效果极佳(截肢率4%,死亡率15%),但在症状出现后6至12小时内接受手术的患者中,效果则较差(截肢率27%,死亡率40%)。症状出现后12至48小时接受手术的患者死亡率(48%)和截肢率(52%)过高。建议对症状出现12小时内就诊的患者所有可能存活的肢体立即进行栓子切除术,但12小时后仅对那些明显有活力(未瘫痪或无感觉异常)的肢体进行手术。其余肢体的替代治疗方法是大剂量静脉注射肝素或尽快截肢。对于症状出现超过60小时就诊的患者,进行栓子切除术的发病率和死亡率较低。