与胃蛋白酶原Pg5基因座的遗传连锁关系。

Genetic linkage relation to the pepsinogen Pg5 locus.

作者信息

Korsnes L, Gedde-Dahl T, Olaisen B, Thorsby E, Olving J, Siverts A, Bratlie A

出版信息

Ann Hum Genet. 1980 Oct;44(2):185-94. doi: 10.1111/j.1469-1809.1980.tb00957.x.

DOI:10.1111/j.1469-1809.1980.tb00957.x

Abstract

Linkage relations between pepsinogen Pg5 and 28 genetic marker loci have been analyzed in Norwegian families. No strong hint of linkage was found. Linkage to Pg5 in males has been ruled out below 25% recombination for HLA and GPT, below 20% recombination for Rh, PGM1, ACP, Gc, MNSs, PGM3, and Gm and Pi, below 15% recombination for Hp, below 10% recombination for Fy, ABO, C3 and Jk and below 4% for Kell, Tf, C6, Km and Le(Se). Possibilities of loose linkages include Pg5-C6 and Pg5-MNSs, both of which should be followed up.

摘要

在挪威家庭中分析了胃蛋白酶原Pg5与28个遗传标记位点之间的连锁关系。未发现明显的连锁迹象。对于男性，已排除HLA和GPT重组率低于25%、Rh、PGM1、ACP、Gc、MNSs、PGM3以及Gm和Pi重组率低于20%、Hp重组率低于15%、Fy、ABO、C3和Jk重组率低于10%以及Kell、Tf、C6、Km和Le(Se)重组率低于4%时与Pg5的连锁。可能存在松散连锁的情况包括Pg5 - C6和Pg5 - MNSs，这两者都应进一步研究。