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用庆大霉素-聚甲基丙烯酸甲酯珠治疗肾功能受损患者。

Treatment of a patient with impaired renal function with gentamicin-PMMA-beads.

作者信息

Walenkamp G H, Vree T B

出版信息

Arch Orthop Trauma Surg (1978). 1981;99(2):137-41. doi: 10.1007/BF00389749.

DOI:10.1007/BF00389749
PMID:7316706
Abstract

150 gentamicin-PMMA-beads were implanted (+ 160 mg gentamicin i.v. preop.) in a woman aged 73 years and with severely impaired kidney function. Frequent determination of gentamicin plasma concentrations and renal functions were possible. The plasma concentration reached a plateau at approx. 3 micrograms/ml. No accumulation of gentamicin in plasma occurred.

摘要

在一名73岁、肾功能严重受损的女性患者中植入了150颗庆大霉素-聚甲基丙烯酸甲酯珠(术前静脉注射160毫克庆大霉素)。可以频繁测定庆大霉素血浆浓度和肾功能。血浆浓度在约3微克/毫升时达到平台期。血浆中未出现庆大霉素蓄积。

相似文献

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Treatment of a patient with impaired renal function with gentamicin-PMMA-beads.用庆大霉素-聚甲基丙烯酸甲酯珠治疗肾功能受损患者。
Arch Orthop Trauma Surg (1978). 1981;99(2):137-41. doi: 10.1007/BF00389749.
2
Gentamicin serum concentrations in patients with gentamicin-PMMA beads for infected hip joints: a prospective observational cohort study.感染性髋关节患者应用庆大霉素-PMMA 珠链后血清中庆大霉素浓度:一项前瞻性观察性队列研究。
Ther Drug Monit. 2012 Feb;34(1):67-71. doi: 10.1097/FTD.0b013e31823d7b89.
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[Treatment of chronic osteomyelitis with gentamicin PMMA chains].庆大霉素聚甲基丙烯酸甲酯链珠治疗慢性骨髓炎
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Gentamicin-impregnated PMMA beads: an introduction and review.庆大霉素负载的聚甲基丙烯酸甲酯珠:介绍与综述。
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Is prophylactic Gentamicin associated with acute kidney injury in patients undergoing surgery for fractured neck of femur?预防性使用庆大霉素是否会导致接受股骨颈骨折手术的患者发生急性肾损伤?
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[The use of gentamicin-polymethylmethacrylate chains for the treatment of soft-tissue wounds in the region of the urinary tract (author's transl)].
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Gentamicin-PMMA beads. Pharmacokinetic and nephrotoxicological study.庆大霉素-聚甲基丙烯酸甲酯珠。药代动力学和肾毒理学研究。
Clin Orthop Relat Res. 1986 Apr(205):171-83.

引用本文的文献

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High systemic gentamicin levels and ototoxicity after implantation of gentamicin beads in a 70-year-old man--a case report.一名70岁男性植入庆大霉素珠后出现高全身庆大霉素水平及耳毒性——病例报告
Acta Orthop. 2009 Dec;80(6):734-6. doi: 10.3109/17453670903487032.
2
Pharmacokinetics: metabolism and renal excretion of quinolones in man.药代动力学:喹诺酮类药物在人体内的代谢及经肾排泄情况
Pharm Weekbl Sci. 1986 Feb 21;8(1):29-34. doi: 10.1007/BF01975476.

本文引用的文献

1
The influence of urine flow on renal clearance of creatinine in patients with normal and impaired kidney function.尿流对肾功能正常和受损患者肌酐肾清除率的影响。
Drug Intell Clin Pharm. 1981 Mar;15(3):194-8. doi: 10.1177/106002808101500305.
2
The release of gentamicin from polymethylmethacrylate beads. An experimental and pharmacokinetic study.庆大霉素从聚甲基丙烯酸甲酯微球中的释放:一项实验与药代动力学研究。
J Bone Joint Surg Br. 1978 May;60-B(2):270-5. doi: 10.1302/0301-620X.60B2.659478.