铊（I）离子的体外移动

Movement of thallium (I) ions in vitro.

Schäfer S G, Nell G, Henning C H

Arch Toxicol. 1981 Nov;48(4):271-9. doi: 10.1007/BF00319655.

Abstract

Movement of thallium (I) ions across the mucosal epithelium of descending rat colon, stripped of the muscularis externa in vitro was determined under voltage clamp conditions. 2. The unidirectional fluxes of thallium (I) ions from mucosal to serosal side (M leads to S) and in the opposite direction (S leads to M) were measured at 0 mV. A net flux of thallium (I) ions was observed from serosal to mucosal side (0.216 nmoles . cm-2 . h-1) in other words, the mucosal epithelium is apparently asymmetric for the movement of thallium (I) ions. 3. The investigations were carried out on the range of -30mV up to +30 mV from mucosal to serosal side. Thallium (I) ions move from mucosal to serosal side (M leads to S) by diffusion only (Pi = 0.119 cm.h-1), whereas into the opposite direction (S leads to M) thallium (I) ions in addition to a voltage-dependent component are transported against an electrical gradient.

摘要

在电压钳制条件下，测定了铊（I）离子在体外去除了外肌层的大鼠降结肠黏膜上皮中的转运情况。2. 在0 mV时测量了铊（I）离子从黏膜侧向浆膜侧（M至S）以及相反方向（S至M）的单向通量。观察到铊（I）离子从浆膜侧向黏膜侧的净通量（0.216纳摩尔·厘米⁻²·小时⁻¹），换句话说，黏膜上皮对于铊（I）离子的转运显然是不对称的。3. 研究在从黏膜侧向浆膜侧-30 mV至+30 mV的范围内进行。铊（I）离子仅通过扩散从黏膜侧向浆膜侧移动（Pi = 0.119厘米·小时⁻¹），而在相反方向（S至M），铊（I）离子除了有电压依赖性成分外，还逆着电梯度转运。