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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Wanitschke R, Nell G, Rummel W

Naunyn Schmiedebergs Arch Pharmacol. 1977 Mar;297(2):191-4. doi: 10.1007/BF00499930.

The dependence of net transfer of water and sodium on hydrostatic pressure gradients from the serosal to the mucosal side was investigated in everted sacs of the stripped mucosa of the rat colon. 2. In the range of 3-20 cm H2O both, net sodium and water transfer were linearly dependent on hydrostatic pressure. The hydraulic permeability coefficient was 1.1 ml per gram dry weight, hour and cm H2O. At a pressure gradient of 5.8 cm H2O the net movement of water from the mucosal to the serosal side ceased. Above this pressure a net movement in the opposite direction occurs. Sodium net movement from the mucosal to the serosal side ceased at 11 cm H2O. The fluid, which appears-driven by higher values of hydrostatic pressure-on the mucosal side, is hypotonic. 3. Oxyphenisation increases the hydraulic permeability of the colonic epithelium. The fluid, which appears--driven by the hydrostatic pressure gradient--on the mucosal side, is isotonic.

在大鼠结肠剥离黏膜外翻囊中，研究了水和钠的净转运对从浆膜侧到黏膜侧静水压力梯度的依赖性。2. 在3 - 20厘米水柱范围内，钠和水的净转运均与静水压力呈线性相关。水力渗透系数为每克干重每小时每厘米水柱1.1毫升。在5.8厘米水柱的压力梯度下，水从黏膜侧向浆膜侧的净移动停止。高于此压力，会出现相反方向的净移动。钠从黏膜侧向浆膜侧的净移动在11厘米水柱时停止。在黏膜侧由较高静水压力驱动出现的液体是低渗的。3. 羟苯乙胺可增加结肠上皮的水力渗透性。在黏膜侧由静水压力梯度驱动出现的液体是等渗的。

Wanitschke R, Nell G, Rummel W

Naunyn Schmiedebergs Arch Pharmacol. 1977 Mar;297(2):191-4. doi: 10.1007/BF00499930.

The dependence of net transfer of water and sodium on hydrostatic pressure gradients from the serosal to the mucosal side was investigated in everted sacs of the stripped mucosa of the rat colon. 2. In the range of 3-20 cm H2O both, net sodium and water transfer were linearly dependent on hydrostatic pressure. The hydraulic permeability coefficient was 1.1 ml per gram dry weight, hour and cm H2O. At a pressure gradient of 5.8 cm H2O the net movement of water from the mucosal to the serosal side ceased. Above this pressure a net movement in the opposite direction occurs. Sodium net movement from the mucosal to the serosal side ceased at 11 cm H2O. The fluid, which appears-driven by higher values of hydrostatic pressure-on the mucosal side, is hypotonic. 3. Oxyphenisation increases the hydraulic permeability of the colonic epithelium. The fluid, which appears--driven by the hydrostatic pressure gradient--on the mucosal side, is isotonic.

在大鼠结肠剥离黏膜外翻囊中，研究了水和钠的净转运对从浆膜侧到黏膜侧静水压力梯度的依赖性。2. 在3 - 20厘米水柱范围内，钠和水的净转运均与静水压力呈线性相关。水力渗透系数为每克干重每小时每厘米水柱1.1毫升。在5.8厘米水柱的压力梯度下，水从黏膜侧向浆膜侧的净移动停止。高于此压力，会出现相反方向的净移动。钠从黏膜侧向浆膜侧的净移动在11厘米水柱时停止。在黏膜侧由较高静水压力驱动出现的液体是低渗的。3. 羟苯乙胺可增加结肠上皮的水力渗透性。在黏膜侧由静水压力梯度驱动出现的液体是等渗的。