关于绵羊对日粮胆碱在消化道吸收前几乎完全被微生物破坏的不敏感性。
On the insensitivity of sheep to the almost complete microbial destruction of dietary choline before alimentary-tract absorption.
作者信息
Dawson R M, Grime D W, Lindsay D B
出版信息
Biochem J. 1981 May 15;196(2):499-504. doi: 10.1042/bj1960499.
Abstract
- Injection of [Me-14C]choline into sheep indicated that the small amount of phosphatidylcholine present in abomasal digesta was largely (69%) of non-dietary or ruminal origin. 2. Long-term feeding of [Me-3H]choline to sheep produced insignificant labelling of plasma phosphatidylcholine, indicating that more than 99% of the choline body pool was of non-dietary origin. 3. In contrast, when rats were fed with [Me-3H]choline for similar periods, 18-54% of the tissue phosphatidylcholine was derived from dietary choline. 4. The loss of [14C]choline and 32P from the plasma phosphatidylcholine after a single injection of these isotopes indicated a markedly slower turnover of choline in the sheep compared with the rat. This observation, coupled with a lack of liver glycerophosphocholine diesterase, provides an explanation for the insensitivity of the sheep to an almost complete microbial destruction of dietary choline before alimentary-tract absorption.
摘要
- 向绵羊注射[甲基 - 14C]胆碱表明，皱胃消化物中存在的少量磷脂酰胆碱大部分（69%）来自非饮食或瘤胃来源。2. 长期给绵羊饲喂[甲基 - 3H]胆碱对血浆磷脂酰胆碱的标记作用不明显，表明胆碱体内池超过99%来自非饮食来源。3. 相比之下，当给大鼠饲喂[甲基 - 3H]胆碱相同时间时，18 - 54%的组织磷脂酰胆碱来自饮食中的胆碱。4. 单次注射这些同位素后，血浆磷脂酰胆碱中[14C]胆碱和32P的损失表明，与大鼠相比，绵羊体内胆碱的周转明显更慢。这一观察结果，再加上缺乏肝脏甘油磷酸胆碱二酯酶，为绵羊对饮食中胆碱在消化道吸收前几乎完全被微生物破坏不敏感提供了解释。
相似文献
1
On the insensitivity of sheep to the almost complete microbial destruction of dietary choline before alimentary-tract absorption.关于绵羊对日粮胆碱在消化道吸收前几乎完全被微生物破坏的不敏感性。
Biochem J. 1981 May 15;196(2):499-504. doi: 10.1042/bj1960499.
2
The low availability of dietary choline for the nutrition of the sheep.绵羊营养中膳食胆碱的低可利用性。
Biochem J. 1979 Jun 15;180(3):559-65. doi: 10.1042/bj1800559.
3
Uptake and output of various forms of choline by organs of the conscious chronically catheterized sheep.清醒的慢性插管绵羊各器官对不同形式胆碱的摄取与输出
Biochem J. 1984 Jan 15;217(2):399-408. doi: 10.1042/bj2170399.
4
Location and secretion of gastric intrinsic factor in the sheep.绵羊胃内因子的定位与分泌
Res Vet Sci. 1981 May;30(3):261-5.
5
Dynamics of protozoa in the rumen of sheep.绵羊瘤胃中原生动物的动态变化
Br J Nutr. 1982 Sep;48(2):399-415. doi: 10.1079/bjn19820123.
6
Mechanism of the enrichment of phosphatidylcholine in liver accompanying enzyme induction by phenobarbital.苯巴比妥诱导酶时肝脏中磷脂酰胆碱富集的机制。
Naunyn Schmiedebergs Arch Pharmacol. 1977 Apr;297(3):275-81. doi: 10.1007/BF00509272.
7
Metabolism of albendazole and albendazole sulphoxide by ruminal and intestinal fluids of sheep and cattle.
Xenobiotica. 1992 Apr;22(4):419-26. doi: 10.3109/00498259209046653.
8
Role of a specific choline pool in sphingomyelin synthesis in rat heart.特定胆碱池在大鼠心脏鞘磷脂合成中的作用
Biochem J. 1977 Dec 15;168(3):387-91. doi: 10.1042/bj1680387.
9
The enterohepatic recycling of bile choline in sheep.绵羊胆汁胆碱的肠肝循环
Comp Biochem Physiol A Comp Physiol. 1987;88(2):283-9. doi: 10.1016/0300-9629(87)90485-3.
10
Brain and serum levels of choline and lecithin resulting from long-term administration.
Neurochem Res. 1986 Apr;11(4):481-8. doi: 10.1007/BF00965317.
引用本文的文献
1
Feeding rumen-protected choline to prepartum Holstein cows in negative energy balance increases circulating lipoprotein phosphatidylcholine and triglyceride concentrations.向处于负能量平衡状态的围产前期荷斯坦奶牛饲喂瘤胃保护性胆碱，可提高循环脂蛋白磷脂酰胆碱和甘油三酯浓度。
JDS Commun. 2025 Mar 3;6(3):304-308. doi: 10.3168/jdsc.2024-0661. eCollection 2025 May.
2
Effects of biocholine powder supplementation in ewe lambs: Growth, rumen fermentation, antioxidant status, and metabolism.在母羊羔中补充生物胆碱粉的效果：生长、瘤胃发酵、抗氧化状态及代谢
Biotechnol Rep (Amst). 2020 Dec 24;29:e00580. doi: 10.1016/j.btre.2020.e00580. eCollection 2021 Mar.
3
Effects of Rumen-Protected Choline on Growth Performance, Carcass Characteristics and Blood Lipid Metabolites of Feedlot Lambs.瘤胃保护性胆碱对育肥羔羊生长性能、胴体特性及血脂代谢产物的影响
Animals (Basel). 2020 Sep 4;10(9):1580. doi: 10.3390/ani10091580.
4
Phosphoethanolamine N-methyltransferase (PMT-1) catalyses the first reaction of a new pathway for phosphocholine biosynthesis in Caenorhabditis elegans.磷酸乙醇胺N-甲基转移酶（PMT-1）催化秀丽隐杆线虫中磷酸胆碱生物合成新途径的第一步反应。
Biochem J. 2007 Jun 15;404(3):439-48. doi: 10.1042/BJ20061815.
5
Uptake and output of various forms of choline by organs of the conscious chronically catheterized sheep.清醒的慢性插管绵羊各器官对不同形式胆碱的摄取与输出
Biochem J. 1984 Jan 15;217(2):399-408. doi: 10.1042/bj2170399.
6
Choline biosynthesis in sheep. Evidence for extrahepatic synthesis.绵羊体内的胆碱生物合成。肝外合成的证据。
Biochem J. 1987 Jun 1;244(2):367-73. doi: 10.1042/bj2440367.
本文引用的文献
1
Improvements in the method of determining individual phospholipids in a complex mixture by successive chemical hydrolyses.通过连续化学水解测定复杂混合物中单个磷脂方法的改进。
Biochem J. 1962 Sep;84(3):497-501. doi: 10.1042/bj0840497.
2
Liver glycerylphosphorylcholine diesterase.肝脏甘油磷酸胆碱二酯酶
Biochem J. 1956 Apr;62(4):689-93. doi: 10.1042/bj0620689.
3
A chemical method for the determination of free choline in plasma.一种测定血浆中游离胆碱的化学方法。
J Biol Chem. 1953 Dec;205(2):803-13.
4
The amounts of glycerylphosphorylcholine in some mammalian tissues.一些哺乳动物组织中甘油磷酰胆碱的含量。
J Biol Chem. 1952 May;197(2):601-9.
5
Passage of protozoa and volatile fatty acids from the rumen of the sheep and from a continuous in vitro fermentation system.原生动物和挥发性脂肪酸从绵羊瘤胃及连续体外发酵系统中的通过情况。
Br J Nutr. 1974 Sep;32(2):341-51. doi: 10.1079/bjn19740087.
6
Attachment of the ciliate Epidinium Crawley to plant fragments in the sheep rumen.纤毛虫艾氏艾美球虫在绵羊瘤胃中附着于植物碎片。
Appl Environ Microbiol. 1976 Sep;32(3):417-22. doi: 10.1128/aem.32.3.417-422.1976.
7
Conversion of choline methyl groups through trimethylamine into methane in the rumen.胆碱甲基基团在瘤胃中通过三甲胺转化为甲烷。
Biochem J. 1978 Mar 15;170(3):529-35. doi: 10.1042/bj1700529.
8
Amino acid catabolism and gluconeogenesis in sheep.绵羊体内的氨基酸分解代谢与糖异生作用
Ann Rech Vet. 1979;10(2-3):376-8.
9
The low availability of dietary choline for the nutrition of the sheep.绵羊营养中膳食胆碱的低可利用性。
Biochem J. 1979 Jun 15;180(3):559-65. doi: 10.1042/bj1800559.
10
The contribution of protozoa to the protein entering the duodenum of sheep.原生动物对进入绵羊十二指肠的蛋白质的贡献。
Br J Nutr. 1979 May;41(3):521-7. doi: 10.1079/bjn19790067.
Zotero 插件