胆碱甲基基团在瘤胃中通过三甲胺转化为甲烷。
Conversion of choline methyl groups through trimethylamine into methane in the rumen.
作者信息
Neill A R, Grime D W, Dawson R M
出版信息
Biochem J. 1978 Mar 15;170(3):529-35. doi: 10.1042/bj1700529.
Abstract
- Choline methyl groups were rapidly metabolized to trimethylamine by rumen micro-organisms. 2. Trimethylamine was further metabolized to methane, but this system was more easily saturated by an excess of substrate, so that trimethylamine accumulated in the rumen of the fed animal. 3. Although trimethylamine was the only intermediate isolated in the conversion of the methyl groups of choline into methane, methylamine also served as a substrate for methane production. 4. The methyl group of methionine was also converted into methane by rumen fluid, but the methyl groups of carnitine were not.
摘要
- 胆碱甲基基团被瘤胃微生物迅速代谢为三甲胺。2. 三甲胺进一步代谢为甲烷，但该系统更容易因底物过量而饱和，从而导致三甲胺在采食动物的瘤胃中积累。3. 虽然三甲胺是胆碱甲基基团转化为甲烷过程中唯一分离出的中间产物，但甲胺也可作为甲烷生成的底物。4. 蛋氨酸的甲基基团也可被瘤胃液转化为甲烷，但肉碱的甲基基团则不能。
相似文献
1
Conversion of choline methyl groups through trimethylamine into methane in the rumen.胆碱甲基基团在瘤胃中通过三甲胺转化为甲烷。
Biochem J. 1978 Mar 15;170(3):529-35. doi: 10.1042/bj1700529.
2
Utilization of trimethylamine and other N-methyl compounds for growth and methane formation by Methanosarcina barkeri.巴氏甲烷八叠球菌利用三甲胺及其他N-甲基化合物进行生长和甲烷生成
Proc Natl Acad Sci U S A. 1979 Jan;76(1):494-8. doi: 10.1073/pnas.76.1.494.
3
Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation.通过改变左旋肉碱的微生物降解来抑制肠道微生物群依赖的促动脉粥样硬化三甲胺 N-氧化物的产生。
Life Sci. 2014 Nov 11;117(2):84-92. doi: 10.1016/j.lfs.2014.09.028. Epub 2014 Oct 7.
4
Occurrence and expression of genes encoding methyl-compound production in rumen bacteria.瘤胃细菌中编码甲基化合物生成的基因的发生与表达
Anim Microbiome. 2019 Nov 14;1(1):15. doi: 10.1186/s42523-019-0016-0.
5
Formation of trideuteromethane from deuterated trimethylamine or methylamine by Methanosarcina barkeri.巴氏甲烷八叠球菌利用氘代三甲胺或甲胺生成三氘甲烷。
J Bacteriol. 1981 Oct;148(1):371-3. doi: 10.1128/jb.148.1.371-373.1981.
6
Deltaproteobacteria (Pelobacter) and Methanococcoides are responsible for choline-dependent methanogenesis in a coastal saltmarsh sediment.德尔塔变形菌（Pelobacter）和产甲烷球菌是沿海盐沼沉积物中胆碱依赖型产甲烷作用的主要贡献者。
ISME J. 2019 Feb;13(2):277-289. doi: 10.1038/s41396-018-0269-8. Epub 2018 Sep 11.
7
Formation of aliphatic amine precursors of N-nitrosodimethylamine after oral administration of choline and choline analogues in the rat.大鼠口服胆碱及胆碱类似物后N-亚硝基二甲胺脂肪胺前体的形成
Food Chem Toxicol. 1989 Jan;27(1):31-4. doi: 10.1016/0278-6915(89)90089-6.
8
Molecular Basis of C-N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase.甘氨酰自由基酶胆碱三甲胺裂解酶切断 C-N 键的分子基础。
Cell Chem Biol. 2016 Oct 20;23(10):1206-1216. doi: 10.1016/j.chembiol.2016.07.020. Epub 2016 Sep 24.
9
New inhibitors of methane production by rumen micro-organisms. Experiments with animals and other practical possibilities.
Br J Nutr. 1975 Nov;34(3):447-57. doi: 10.1017/s0007114575000505.
10
Nitrate and sulfate: Effective alternative hydrogen sinks for mitigation of ruminal methane production in sheep.硝酸盐和硫酸盐：缓解绵羊瘤胃甲烷生成的有效替代氢汇。
J Dairy Sci. 2010 Dec;93(12):5856-66. doi: 10.3168/jds.2010-3281.
引用本文的文献
1
Methyl-Based Methanogenesis: an Ecological and Genomic Review.基于甲基的产甲烷作用：生态与基因组学综述。
Microbiol Mol Biol Rev. 2023 Mar 21;87(1):e0002422. doi: 10.1128/mmbr.00024-22. Epub 2023 Jan 24.
2
Prevotella: A Key Player in Ruminal Metabolism.普雷沃氏菌属：瘤胃代谢中的关键参与者。
Microorganisms. 2022 Dec 20;11(1):1. doi: 10.3390/microorganisms11010001.
3
Methane Reduction Potential of Brown Seaweeds and Their Influence on Nutrient Degradation and Microbiota Composition in a Rumen Simulation Technique.褐藻的甲烷减排潜力及其对瘤胃模拟技术中营养物质降解和微生物群组成的影响
Front Microbiol. 2022 Jun 28;13:889618. doi: 10.3389/fmicb.2022.889618. eCollection 2022.
4
Bovine host genome acts on rumen microbiome function linked to methane emissions.牛的宿主基因组作用于与甲烷排放有关的瘤胃微生物组功能。
Commun Biol. 2022 Apr 12;5(1):350. doi: 10.1038/s42003-022-03293-0.
5
Methane emissions and rumen metabolite concentrations in cattle fed two different silages.给牛饲喂两种不同青贮料时甲烷排放量和瘤胃液代谢物浓度的变化
Sci Rep. 2022 Mar 31;12(1):5441. doi: 10.1038/s41598-022-09108-w.
6
Diverse methylotrophic methanogenic archaea cause high methane emissions from seagrass meadows.多样的甲基营养产甲烷古菌导致海草草甸的甲烷排放量很高。
Proc Natl Acad Sci U S A. 2022 Mar 1;119(9). doi: 10.1073/pnas.2106628119.
7
The rumen microbiome inhibits methane formation through dietary choline supplementation.瘤胃微生物组通过膳食胆碱补充抑制甲烷生成。
Sci Rep. 2021 Nov 5;11(1):21761. doi: 10.1038/s41598-021-01031-w.
8
Using Structural Equation Modeling to Understand Interactions Between Bacterial and Archaeal Populations and Volatile Fatty Acid Proportions in the Rumen.使用结构方程模型理解瘤胃中细菌和古菌种群与挥发性脂肪酸比例之间的相互作用。
Front Microbiol. 2021 Jun 9;12:611951. doi: 10.3389/fmicb.2021.611951. eCollection 2021.
9
Occurrence and expression of genes encoding methyl-compound production in rumen bacteria.瘤胃细菌中编码甲基化合物生成的基因的发生与表达
Anim Microbiome. 2019 Nov 14;1(1):15. doi: 10.1186/s42523-019-0016-0.
10
Effects of biocholine powder supplementation in ewe lambs: Growth, rumen fermentation, antioxidant status, and metabolism.在母羊羔中补充生物胆碱粉的效果：生长、瘤胃发酵、抗氧化状态及代谢
Biotechnol Rep (Amst). 2020 Dec 24;29:e00580. doi: 10.1016/j.btre.2020.e00580. eCollection 2021 Mar.
本文引用的文献
1
Studies on ruminant saliva. 1. The composition and output of sheep's saliva.反刍动物唾液的研究。1. 绵羊唾液的成分与分泌量。
Biochem J. 1948;43(1):99-109.
2
The Formation of Trimethylamine from Choline as a Characteristic of Shigella Alkalescens.由胆碱形成三甲胺作为碱性志贺氏菌的一个特征
J Bacteriol. 1944 Mar;47(3):309-10. doi: 10.1128/jb.47.3.309-310.1944.
3
The action of members of the genus Achromobacter on trimethylamine oxide and related compounds.无色杆菌属成员对氧化三甲胺及相关化合物的作用。
J Bacteriol. 1951 Aug;62(2):249-51. doi: 10.1128/jb.62.2.249-251.1951.
4
Studies on the methane fermentation. IX. The origin of methane in the acetate and methanol fermentations by methanosarcina.甲烷发酵研究。IX. 甲烷八叠球菌在乙酸盐和甲醇发酵中甲烷的起源。
J Bacteriol. 1951 Jan;61(1):81-6. doi: 10.1128/jb.61.1.81-86.1951.
5
Choline fermentation by Desulfovibrio desulfuricans.脱硫弧菌进行胆碱发酵
J Bacteriol. 1962 Nov;84(5):973-8. doi: 10.1128/jb.84.5.973-978.1962.
6
Anaerobic degradation of choline. I. Fermentation of choline by an anaerobic, cytochrome-producing bacterium, Vibrio cholinicus n. sp.胆碱的厌氧降解。I. 一种产细胞色素的厌氧菌——霍乱弧菌新种对胆碱的发酵作用
J Bacteriol. 1959 Oct;78(4):557-61. doi: 10.1128/jb.78.4.557-561.1959.
7
A hydrolytic procedure for the identification and estimation of individual phospholipids in biological samples.一种用于鉴定和估算生物样品中单个磷脂的水解方法。
Biochem J. 1960 Apr;75(1):45-53. doi: 10.1042/bj0750045.
8
A simple method for the isolation and purification of total lipides from animal tissues.一种从动物组织中分离和纯化总脂质的简单方法。
J Biol Chem. 1957 May;226(1):497-509.
9
[Choline catabolism induced by intestinal flora in pigs; study of some inhibitors].[猪肠道菌群诱导的胆碱分解代谢；某些抑制剂的研究]
C R Hebd Seances Acad Sci. 1956 Jun 11;242(24):2883-6.
10
Bacterial degradation of choline.
Nature. 1953 Mar 28;171(4352):573-4. doi: 10.1038/171573b0.
Zotero 插件