Fitzpatrick J M, Wallace D M, Whitfield H N, Watkinson L E, Fernando A R, Wickham J E
Br J Urol. 1981 Dec;53(6):524-7. doi: 10.1111/j.1464-410x.1981.tb03253.x.
Inosine, a purine nucleotide, has been used in 33 patients as a method of preventing ischaemic renal damage. The long-term results have been reviewed with a mean follow-up of 28 months. Inosine was administered either intra-arterially or intravenously. Renal function was assessed by serum creatinine, creatinine clearance and divided function renography. Inosine afforded satisfactory protection in ischaemic periods of up to 60 min, particularly if pre-operative function was normal. It was less reliable if pre-operative function was poor or in ischaemic periods greater than 60 min. Inosine is a helpful aid in ischaemic renal surgery.
肌苷，一种嘌呤核苷酸，已被用于33例患者，作为预防缺血性肾损伤的一种方法。已对长期结果进行了回顾，平均随访28个月。肌苷通过动脉内或静脉内给药。通过血清肌酐、肌酐清除率和分肾功能肾图评估肾功能。肌苷在长达60分钟的缺血期提供了令人满意的保护，特别是如果术前肾功能正常。如果术前功能较差或缺血期超过60分钟，其可靠性较低。肌苷在缺血性肾脏手术中是一种有用的辅助手段。
