Beskrovnyĭ A M, Sukacheva O A
Probl Endokrinol (Mosk). 1977 Sep-Oct;23(5):62-5.
It was experimentally revealed that 1-thyroxin administered in combination with an antithyroid preparation caused no depression of the thyrotropic function of the hypophysis whose activation was caused by the inhibitory action of the antithyroid agent on the thyroid gland. At the same time combined administration of the preparations failed to lead to the thyroxin inactivation. The "block effect" of the hypophysis response to the thyroxin administration persisted even with such low doses of antithyroid preparation which failed to depress the thyroid function, and, correspondingly, did not activate the thyrotropic hormone production by the hypophysis.
实验表明，1-甲状腺素与抗甲状腺制剂联合给药时，垂体促甲状腺功能并未因抗甲状腺剂对甲状腺的抑制作用所引发的激活而受到抑制。同时，联合给药也未导致甲状腺素失活。即使使用低剂量的抗甲状腺制剂，垂体对甲状腺素给药的反应“阻断效应”仍然存在，而这种低剂量的抗甲状腺制剂并不会抑制甲状腺功能，相应地也不会激活垂体促甲状腺激素的分泌。
