Kuwajima I, Ueda K, Kamata C, Matsushita S, Kuramoto K, Murakami M, Hada Y
Jpn Heart J. 1978 Jul;19(4):455-67. doi: 10.1536/ihj.19.455.
Ten mg of Nifedipine, a Ca++ antagonist, was administered orally in 2 groups of patients; Group 1: 6 patients in hypertensive emergency and Group II: 12 patients with intractable, severe hypertension. Following results were obtained. 1) A marked hypotensive effect was observed in all patients of Group I. The maximum effect was observed within 30 to 60 min and lasted for approximately 180 min. Clinical symptoms also improved remarkably with the fall in blood pressure. Any side effect was not observed. 2) A marked hypotensive effect was observed in all cases of Group II. The blood pressure fell by 21.4% systolic (p less than 0.01) and 19.4% diastolic (p less than 0.02). The peripheral vascular resistance also showed the decrease by 26.2% (p less than 0.01). The heart rate and cardiac index increased slightly. It was suggested that the hypotensive mechanism of this preparation is due primarily to the peripheral vasodilation.
给两组患者口服10毫克钙拮抗剂硝苯地平；第一组：6例高血压急症患者；第二组：12例顽固性重度高血压患者。得到以下结果。1）第一组所有患者均观察到显著的降压效果。最大效果在30至60分钟内观察到，持续约180分钟。随着血压下降，临床症状也明显改善。未观察到任何副作用。2）第二组所有病例均观察到显著的降压效果。收缩压下降21.4%（p<0.01），舒张压下降19.4%（p<0.02）。外周血管阻力也下降了26.2%（p<0.01）。心率和心脏指数略有增加。提示该制剂的降压机制主要是由于外周血管扩张。
