Batra S, Müntzing J
Eur J Pharmacol. 1981 Nov 19;76(1):87-91. doi: 10.1016/0014-2999(81)90013-3.
The radioactivity following a single i.v. injection of 45Ca into male rats was found to be significantly higher in seminal vesicles, dorsolateral prostate, coagulating glands and ventral prostate than in muscle. The acute effect of a single dose given intraperitoneally of estramustine phosphate (Estracyt) and diethylstilbestrol diphosphate (Honvan) were examined on 45Ca uptake. Generally, the 45Ca concentration in the accessory sex organs with the exception of the dorsolateral prostate increased after administration of estramustine phosphate. Diethylstilbestrol phosphate treatment also significantly increased 45Ca uptake in the ventral prostate when measured on the basis of tissue wet weight but not on the basis of protein. The implications of these findings are discussed in relation to the therapeutic action of Estracyt in prostatic carcinoma.
给雄性大鼠单次静脉注射45Ca后，发现精囊、背外侧前列腺、凝固腺和腹侧前列腺中的放射性明显高于肌肉。研究了腹腔注射磷酸雌莫司汀（艾去适）和己烯雌酚二磷酸酯（己烷雌酚）单次给药对45Ca摄取的急性影响。一般来说，除背外侧前列腺外，给予磷酸雌莫司汀后，附属生殖器官中的45Ca浓度会增加。以组织湿重为基础测量时，磷酸己烯雌酚处理也显著增加了腹侧前列腺对45Ca的摄取，但以蛋白质为基础测量时则不然。结合艾去适在前列腺癌中的治疗作用对这些发现的意义进行了讨论。
