Wing E J
Immunology. 1981 Nov;44(3):509-15.
Bacillus Calmette-Guérin (BCG) inoculation has been shown to inhibit certain immune functions. To determine whether this inhibition adversely affects host defences against infection, the effect of BCG on Listeria infection in mice was investigated. Mice were injected intravenously (i.v.) with Listeria monocytogenes and 24-96 hr later were inoculated with 8 x 10(6) BCG. Mice given BCG and Listeria had a greater mortality and higher spleen Listeria counts than mice given Listeria alone. An increased number of bacteria in spleens was noted as early as 24 hr after BCG inoculation. Peritoneal macrophages from mice receiving both organisms had a decreased capacity to kill Listeria in vitro. In addition, BCG inoculation suppressed delayed hypersensitivity responses and in vitro spleen cell proliferative responses to Listeria antigen. Suppression of spleen cell proliferative responses was associated with an adherent, non-T lymphocyte subpopulation. The data indicate that BCG administration decreases resistance to intracellular pathogens by abrogating normal cellular defences.
卡介苗接种已被证明会抑制某些免疫功能。为了确定这种抑制是否会对宿主抗感染防御产生不利影响，研究了卡介苗对小鼠李斯特菌感染的影响。给小鼠静脉注射单核细胞增生李斯特菌，24至96小时后接种8×10⁶个卡介苗。同时接种卡介苗和李斯特菌的小鼠比仅接种李斯特菌的小鼠死亡率更高，脾脏中的李斯特菌数量也更多。早在接种卡介苗24小时后，脾脏中的细菌数量就有所增加。同时接受两种病原体的小鼠的腹腔巨噬细胞在体外杀灭李斯特菌的能力下降。此外，卡介苗接种抑制了迟发型超敏反应以及体外脾脏细胞对李斯特菌抗原的增殖反应。脾脏细胞增殖反应的抑制与一个黏附性非T淋巴细胞亚群有关。数据表明，接种卡介苗会通过消除正常的细胞防御机制降低对细胞内病原体的抵抗力。
