Baker L A, Campbell P A
Infect Immun. 1980 Feb;27(2):455-60. doi: 10.1128/iai.27.2.455-460.1980.
Brewer thioglycolate medium, a bacterial culture medium which is widely used as a nonspecific in vivo macrophage stimulant, was tested for its effect on mouse resistance to bacterial infection. Mice which did or did not receive thioglycolate medium were challenged with Listeria monocytogenes. Injection of thioglycolate medium significantly decreased the ability of the host to resist infection. This decreased resistance occurred whether thioglycolate medium was injected 0 to 9 days before, or 1 to 2 h after Listeria challenge. Bacteria grew considerably better in washed adherent peritoneal cells from thioglycolate medium-injected mice than in washed adherent peritoneal cells from normal mice. Thus, thioglycolate medium may ultimately cause a decrease in macrophage function.
布鲁尔巯基乙酸盐培养基是一种被广泛用作非特异性体内巨噬细胞刺激剂的细菌培养基，该培养基对小鼠抵抗细菌感染的作用进行了测试。给小鼠注射或不注射巯基乙酸盐培养基，然后用单核细胞增生李斯特菌进行攻击。注射巯基乙酸盐培养基显著降低了宿主抵抗感染的能力。无论在李斯特菌攻击前0至9天或攻击后1至2小时注射巯基乙酸盐培养基，都会出现这种抵抗力下降的情况。与正常小鼠的洗涤贴壁腹膜细胞相比，来自注射巯基乙酸盐培养基小鼠的洗涤贴壁腹膜细胞中的细菌生长得要好得多。因此，巯基乙酸盐培养基最终可能会导致巨噬细胞功能下降。
