Cephalosporins. III. Synthesis and structure-activity relationships of 7-vinylenethioacetamid:o cephalosporins with a tetrazolo-pyridazine at the 3-position.
作者信息
Nannini G, Perrone E, Severino D, Casabuona F, Bedeschi A, Buzzetti F, Giraldi P N, Meinardi G, Monti G, Ceriani A, de Carneri I
出版信息
J Antibiot (Tokyo). 1981 Nov;34(11):1456-68. doi: 10.7164/antibiotics.34.1456.
PMID:7319908
Abstract
The synthesis and in vitro activity of 7-vinylenethioacetamido cephalosporins with a tetrazolo-pyridazine at the 3-position are described. These cephalosporins showed good activity against Gram-positive and Gram-negative bacteria. 7-[(Z)-beta-carboxyvinylenethio-acetamido]-3-[(tetrazolo[1,5-b]pyridazin-8- amino-6-yl)-thiomethyl]-3-cephem-4-carboxylic acid (K 13176, 21) was significantly more active in vitro and in vivo than cefazolin against Gram-negative bacteria.
摘要
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