在3位和4位修饰的新型利福霉素。合成、结构及生物学评价。
New rifamycins modified at positions 3 and 4. Synthesis, structure and biological evaluation.
作者信息
Marsili L, Pasqualucci C R, Vigevani A, Gioia B, Schioppacassi G, Oronzo G
出版信息
J Antibiot (Tokyo). 1981 Aug;34(8):1033-8. doi: 10.7164/antibiotics.34.1033.
PMID:7319919
Abstract
A number of semisynthetic rifamycin derivatives modified at positions 3 and/or 4, belonging to general structures 3, 5, and 6 (see Scheme 1), have been prepared. The synthesis, structure and antimicrobial evaluation of the new compounds are described. All the derivatives have "in vitro" antibacterial activities well comparable with that of rifampicin.
摘要
已经制备了一些在3位和/或4位修饰的半合成利福霉素衍生物，它们属于通式3、5和6（见方案1）。描述了新化合物的合成、结构和抗菌评价。所有衍生物的“体外”抗菌活性与利福平相当。
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