Oyster C W, Takahashi E S, Hurst D C
J Neurosci. 1981 Dec;1(12):1331-46. doi: 10.1523/JNEUROSCI.01-12-01331.1981.
Cell soma area or diameter distributions are generally very skewed and present some unusual problems in characterization and description. In this study of ganglion cell soma size in rabbit retina, our conclusions are based on a statistical method which not only characterizes this particular neuronal population but which also may be of considerable value in other species and other parts of the nervous system. To facilitate comparisons between retinas, we used ganglion cell density as the measure of retinal location. The rabbit retina has a horizontally extended area centralis, the visual streak, which we show to have a uniformly high peak cell density along most of its length. Cell density maps were used to estimate the total number of ganglion cells in the retina; the mean for three retinas was about 406,000 cells, which corresponds well to an earlier count of optic nerve axons (394,000 +/- 20,000; Vaney, D.I., and A. Hughes (1976) J. Comp. Neurol. 170: 241-252). Contrary to other reports, we could not find any large differences in ganglion cell size distributions between the inferior peripheral retina and the visual streak nor could we confirm the report of a large cell area temporalis (Provis, J. M. (1979) J. Comp. Neurol. 185: 121-138). Cell size distributions in the superior and inferior retina were very different, however, and, within the inferior retina, there was a small but systematic change in cell size between the periphery and the visual streak. In general, small and medium size cells were present in nearly constant proportions throughout the inferior retina, while the large ganglion cells showed a small decrease in proportion from the periphery to the visual streak; the decline in large cells was a linear function of cell density. In terms of ganglion cell soma size, there was no sharp distinction between the visual streak and the peripheral retina.
细胞体面积或直径分布通常非常不对称，在特征描述方面存在一些特殊问题。在这项对兔视网膜神经节细胞体大小的研究中，我们的结论基于一种统计方法，该方法不仅可以描述这一特定神经元群体的特征，而且在其他物种和神经系统的其他部位也可能具有重要价值。为便于视网膜之间的比较，我们使用神经节细胞密度作为视网膜位置的衡量指标。兔视网膜有一个水平延伸的中央区，即视带，我们发现视带在其大部分长度上具有均匀较高的峰值细胞密度。细胞密度图用于估计视网膜中神经节细胞的总数；三个视网膜的平均值约为406,000个细胞，这与早期对视神经轴突数量的计数结果（394,000±20,000；Vaney, D.I.和A. Hughes（1976年）《比较神经学杂志》170: 241 - 252）非常吻合。与其他报告相反，我们未发现周边下部视网膜与视带之间神经节细胞大小分布存在任何显著差异，也无法证实有关颞侧大细胞区的报告（Provis, J.M.（1979年）《比较神经学杂志》185: 121 - 138）。然而，上部和下部视网膜中的细胞大小分布差异很大，并且在下部视网膜内，从周边到视带细胞大小存在微小但有规律的变化。一般来说，中小尺寸细胞在整个下部视网膜中的比例几乎恒定，而大神经节细胞的比例从周边到视带略有下降；大细胞数量的下降是细胞密度的线性函数。就神经节细胞体大小而言，视带和周边视网膜之间没有明显区别。
