Eschenbach C
Monatsschr Kinderheilkd. 1981 Nov;129(11):640-4.
Chemoluminescence (CL) measurement of phagocytozing polymorphonuclear leukocytes (PMN) is used to determine the activity of intracellular O2-dependent bactericidal capacity. PMN in the cordblood of healthy neonates compared to those of healthy adults is significantly decreased but kinectically normal. Phagocytozing PMN of infected neonates produce CL in a distinctly lower degree than those from the cordblood of healthy neonates. This pronounced depression of CL is a temporary event during bacterial infections, the CL reaction is also retarded. On the contrary phagocytozing PMN of older children and adults show an increase of CL production during bacterial infections. The described pattern of the oxidative metabolism reacting to bacterial infections on the neonatal period shows a reduced bactericidal capacity of these cells due to bacterial infections. Probably this pattern is one cause of increased letality and morbidity observed in bacterial infections of the newborn.
采用化学发光（CL）法检测吞噬多形核白细胞（PMN），以确定细胞内氧依赖性杀菌能力的活性。与健康成年人相比，健康新生儿脐带血中的PMN显著减少，但动力学正常。受感染新生儿的吞噬PMN产生CL的程度明显低于健康新生儿脐带血中的PMN。CL的这种明显降低是细菌感染期间的一个暂时现象，CL反应也会延迟。相反，大龄儿童和成年人的吞噬PMN在细菌感染期间CL产生增加。所述新生儿期对细菌感染的氧化代谢反应模式表明，由于细菌感染，这些细胞的杀菌能力降低。这种模式可能是新生儿细菌感染中观察到的死亡率和发病率增加的一个原因。
