Nisticò G, De Sarro G B, Naccari F, Musolino R, Rotiroti D, Gallitto G, Di Perri R
Monogr Neural Sci. 1980;5:14-9. doi: 10.1159/000387477.
In various animal species (chicks, rats and rabbits) the intravenous injection of high doses of cefazolin, a cephalosporin not hitherto reported to produce epileptic seizures, was found to produce epileptiform electrocortrical changes similar to those evoked by intravenous benzylpenicillin. Similar phenomena as those reported after systemic injection were also observed after microinjection of cefazolin into the III cerebral ventricle. In fact, both in chicks and rats cefazolin given by the latter route produced wild running crisis, myoclonic jerks of the limbs and in some instances generalized clonic convulsions. Concomitantly, bilateral electrocortical high voltage bursts of spikes were observed, followed during the intercritic period by periodic bilateral or unilateral single spikes.
在多种动物物种（小鸡、大鼠和兔子）中，静脉注射高剂量的头孢唑林（一种迄今未报道会引发癫痫发作的头孢菌素）被发现会产生类似于静脉注射苄青霉素所诱发的癫痫样皮层电变化。将头孢唑林微量注射到第三脑室后，也观察到了与全身注射后报道的类似现象。事实上，通过后一种途径给予头孢唑林，在小鸡和大鼠中都会引发狂奔发作、四肢肌阵挛性抽搐，在某些情况下还会出现全身性阵挛性惊厥。与此同时，观察到双侧皮层出现高电压棘波爆发，在发作间期则会出现周期性的双侧或单侧单个棘波。
