Balázs M, Csermely A
Morphol Igazsagugyi Orv Sz. 1981 Oct;21(4):241-9.
Ultrastructural characteristics of premalignant epithelial dysplasia were studied electronmicroscopically by comparing epithelial cells of adenomatous- and adenopapillary polyps. In adenomatous polyps the rate of absorptive and goblet cells, their electron microscopic appearance did not differ from those of the normal colonic mucosa. In dysplastic areas of adenopapillary polyps severe proliferation of undifferentiated epithelial cells and disturbance of the maturation of absorptive and goblet cells was found. Severe damage to the cell membrane, atypical vacuola and dense bodies in the apical areas of absorptive cells were also seen. An abundance of Leuchtenberger's inclusion bodies as an important sign of the malignant transformation have occurred.
通过比较腺瘤性息肉和腺乳头状息肉的上皮细胞，用电镜研究了癌前上皮发育异常的超微结构特征。在腺瘤性息肉中，吸收细胞和杯状细胞的比例及其电镜下表现与正常结肠黏膜无异。在腺乳头状息肉的发育异常区域，发现未分化上皮细胞严重增殖，吸收细胞和杯状细胞成熟障碍。还可见吸收细胞顶端区域细胞膜严重受损、非典型空泡和致密体。出现了大量勒滕伯格包涵体，这是恶性转化的一个重要标志。
